Results 191 to 200 of about 9,035 (208)

A Perspective on Covalent Hit Identification and Validation in the European Pharmaceutical Industry. [PDF]

Chembiochem
Schadt O, Essig S, Testolin G.
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Memories about the Academy of Medical Sciences since its reestablishment - July 1969. [PDF]

Med Pharm Rep
Baltă N.
europepmc   +1 more source

Quantitative Systems Pharmacology (QSP): Bridging Biology and Mechanism with Clinical Drug Development Decisions. [PDF]

J Clin Pharmacol
Wang W, Ratushny AV, Chang S, Cheng Y, Gong JQX, Gulati A, Hansson E, Kulesza A, Reali F, Sandefur C, Schmidt BJ, Singh FA, Susilo ME, Zaph S, Shtylla B.   +14 more
europepmc   +1 more source

Structure and evolution-guided design of minimal RNA-guided nucleases. [PDF]

Science
Skopintsev P, Esain-Garcia I, DeTurk EC, Yoon PH, Zhou Z, Weiss T, Kamalu M, Chamraj A, Loi KJ, Langeberg CJ, Boger RS, Nisonoff H, Karp HM, Chen LX, Shi H, Vohra K, Banfield JF, Cate JHD, Jacobsen SE, Jacobsen SE, Doudna JA.   +20 more
europepmc   +1 more source

Current Practices and Considerations for Benchmarking Human Gastrointestinal Organoids. [PDF]

Cell Mol Gastroenterol Hepatol
Brown ME, Gleizes AR, Yu Q, Adhikari UD, Nagarajan R, Rout P, Camp JG, Yilmaz OH, Tape CJ, Tyska MJ, Verzi MP, Lau KS, Gracz AD.   +12 more
europepmc   +1 more source

Stratodynamics: A New Theory of Layered Biological Response. [PDF]

Biology (Basel)
Ametaj BN.
europepmc   +1 more source

Mechanisms restricting hepatitis B virus cross-species transmission. [PDF]

mBio
Ijoma JN, Gomez-Moreno A, Ayoub S, Ploss A.   +3 more
europepmc   +1 more source

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An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

Ca-A Cancer Journal for Clinicians, 2022
Marion Smits, Jeffrey Weinberg, James B Yu   +2 more
exaly