Results 81 to 90 of about 77,933 (256)

A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment

iScience
Summary: Phagocytosis is the process of actin-dependent internalization and degradation of large particles. Macrophages, which are professional phagocytes, are present in all tissues and are, thus, exposed to environments with different mechanical ...
Manon Depierre, Anna Mularski, Artur Ruppel, Christophe Le Clainche, Martial Balland, Florence Niedergang   +5 more
doaj   +1 more source

Emerging Areas of Nursing Science and PhD Education for The 21\u3csup\u3est\u3c/sup\u3e Century: Response to Commentaries [PDF]

, 2015
We respond to commentaries from the American Academy of Nursing, the American Association of Colleges of Nursing, and the National Institute of Nursing Research on our thoughts about integrating emerging areas of science into nursing PhD programs.
Alt-White, Anna C., Conley, Yvette P., Dunbar-Jacob, Jacqueline, Heitkemper, Margaret M., Henly, Susan J., McCarthy, Ann Marie, McCarthy, Donna O., Moore, Shirley M., Redeker, Nancy S., Stone, Patricia W., Titler, Marita, Titler, Marita G., Wyman, Jean F.   +12 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions

iScience
Summary: The mechanisms underlying the pathophysiology of endometriosis, characterized by the presence of endometrium-like tissue outside the uterus, remain poorly understood.
Gregory W. Burns, Zhen Fu, Erin L. Vegter, Zachary B. Madaj, Erin Greaves, Idhaliz Flores, Asgerally T. Fazleabas   +6 more
doaj   +1 more source

Calumenin-1 Interacts with Climp63 to Cooperatively Determine the Luminal Width and Distribution of Endoplasmic Reticulum Sheets

iScience, 2019
Summary: The ER is composed of distinct structures like tubules, matrices, and sheets, all of which are important for its various functions. However, how these distinct ER structures, especially the perinuclear ER sheets, are formed remains unclear.
Birong Shen, Pengli Zheng, Nannan Qian, Qingzhou Chen, Xin Zhou, Junjie Hu, Jianguo Chen, Junlin Teng   +7 more
doaj   +1 more source

Magnetism, FeS colloids, and Origins of Life

, 2010
A number of features of living systems: reversible interactions and weak bonds underlying motor-dynamics; gel-sol transitions; cellular connected fractal organization; asymmetry in interactions and organization; quantum coherent phenomena; to name some ...
A Ahniyaz, A Engel, A Etxeberria, A Nagya, A Preisinger, A Pross, A Yethiraj, AD Patel, AD Patel, AD Patel, AG Cairns-Smith, AJ Boyce, AJ Boyce, AL Buchachenko, AM Selvam, AM Tishin, AP Roberts, AS Keys, AY Zubarev, AY Zubarev, B-O Küppers, BA Grzybowski, C Bustamante, C Huber, C Jaryznski, C Tenailleau, C Viedma, CR Vestal, D Abel, D Abel, D Rickard, D Rickard, D Rickard, den Hollander WThF, DG Drubin, DI Khomskii, DJ Vaughan, DJ Vaughan, DL Stein, DS Kelley, E Schroedinger, EJ Milner-White, EJ Milner-White, ET Degens, EV Koonin, F Heylighen, FJ Dyson, FM Harold, G Mitra-Delmotte, G Nicolis, G Wächtershäuser, GL Früh-Green, GN Ling, GO Arrhenius, GS Engel, H Frohlich, H Frohlich, H Ohfuji, H Ohfuji, H Ohldag, HH Pattee, HH Pattee, HM Palmer, I Adler, I Kant, IK Kominis, J Al-Khalili, J Breivik, J Charnock, J Cheon, J Dyment, J Hemberger, J Higo, J Hoffmeyer, J Li, J McFadden, J Spitzer, J Torbet, JC Weaver, JD Bernal, JK Jain, JL Kirschvink, JL Kirschvink, JL Kirschvink, JM McBride, JP Ferris, JS Ban, JS Beard, JT Trevors, K Hatori, K Matsuno, K Righter, KA Michie, KM Doll, LE Orgel, LE Orgel, LE Orgel, LS Levitov, M Haw, M Jibu, M Mostovoy, M Polyani, M Winkelhofer, M Wolthers, M Wu, MF Chaplin, MF Chaplin, Mitra-Delmotte, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MO Goerbig, MP Pileni, NE Mavromatos, NJ Cerf, P Baaske, P Bak, P Galland, P Wasilewski, PCW Davies, PCW Davies, PCW Davies, PW Anderson, R Hazen, R Kopelman, R Lifshitz, R Palm, R Pastor-Satorras, R Phillips, R Shapiro, R Skomski, RA Dunlap, RCL Larter, RD Astumian, RD Astumian, RE Rosensweig, RT Wilkin, RW Chantrell, S Hagan, S Itoh, S Kauffman, S Lloyd, S Odenbach, S Sun, S Taketomi, S Traverso, SA Newman, T Schroeder, V Fritsch, V Hoffmann, VK Mer La, VM Goldschmidt, VN Manoharan, VTh Marteinsson, VV Korolev, W Cruz da, W Martin, W Martin, WH Zurek, Y Kwon, Y Lalatonne, Y Min, Z Merali, Z Sawlowicz, Z Sawlowicz, Z Wang   +172 more
core   +1 more source

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

The MO25 protein Pmo25 functions in contractile ring stability and Sid2 localization during cytokinesis

iScience
Summary: Mouse protein-25 (MO25) family proteins are crucial in development and morphogenesis from plants to humans. The fission yeast MO25 protein Pmo25 is essential for cell polarity and division.
Yanfang Ye, Sha Zhang, Jack R. Gregory, Aysha H. Osmani, Evelyn G. Goodyear, Davinder Singh, Jian-Qiu Wu   +6 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source