Results 181 to 190 of about 18,038,776 (359)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Optimising Models of Management by Organizational Changes

, 2019
V A Dolyatovskiy, V S Barnagjan, L V Dolyatovskiy   +2 more
openalex   +1 more source

Changing organizational culture in terms of information and communications technologies [PDF]

Organizational change can be considered a genuine moment of evolution and development of the entire organization and decision of change is closely related to the company's mission, the objectives that wish to achieve in order to ensure their competitive ...
Daniel Boldureanu, Gabriela Boldureanu, Nicoleta Niculescu, Teodor Paduraru   +3 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Relation Between Emotional Intelligence and Personality on Attitude Towards Organizational Change

, 2023
Kamaljeet Kaur Bhatia
openalex   +2 more sources

Measuring the Managerial Potential [PDF]

The paper proposes the measurement of managerial and functional capabilities of the organization, as the dimensions of managerial potential, based on the configurative theory and not on the reductionist one. The components of the managerial potential are
George Moldoveanu, Ion Gh. Rosca
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Unravelling the relationship between perceived values-congruence with organizational change readiness: A moderated mediation model. [PDF]

Front Psychol, 2023
Deng J, Cheng Z, Qi S, Deng R.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Comprehensive trauma-informed organizational change at an academic medical center in South Texas. [PDF]

BMC Health Serv Res
Sebton SA, Bridger CM, Arias PA, Okeibunor CK, Spencer SR, Willis RE, Taylor SE, Alsip BJ.   +7 more
europepmc   +1 more source