Results 31 to 40 of about 259,153 (311)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Change, Resistance to Change and Organizational Cynicism

open access: yesStudies in Business and Economics, 2016
Over the past decades, the focus of the scientists has shifted towards the area of organizational change. The concept has been approached from several perspectives and studied by numerous disciplines and refers to a shift or transformation of an ...
Grama Blanca, Todericiu Ramona
doaj   +1 more source

THE TASKS OF REVIEWING AND FINDING THE RIGHT ORGANIZATIONAL CHANGE THEORY

open access: yesInternational Journal of Educational Leadership and Management, 2017
Organizational change is probably the singular most important undertaken that many organizations wish they could do to affect their productivities/profitability performances.
Abayomi Oluwatosin Alase
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Prospect theory as an explanation for resistance to organizational change: some management implications [PDF]

open access: yesProblems and Perspectives in Management, 2016
The problem in organizational change projects is that people often resist organizational change. Many change projects in organizations do not reach their goals. The question is why?
Daniel J. Adriaenssen   +1 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Framework for Organizational Change [PDF]

open access: yesمطالعات مدیریت راهبردی, 2015
Having an integrated model of change management can simplify the inherent complexity of change by recognizing the relation between critical elements. Because of dynamic nature of variables and their interaction, developing a static model is not useful ...
Hanieh Arazmjoo   +2 more
doaj  

Identifying predictors of resistance to organizational change [PDF]

open access: yes, 2004
Plan BChange is occurring in all organizations today. However, many change efforts fail due to resistance from employees. The purpose of this study is to determine the predictors of resistance to change.
Johannsen, Ashlee M.
core  

Human resource training and its effect on the integration and success of organizational change

open access: yes, 2023
HR trainings play a pivotal role in the successful implementation of organizational change. These trainings equip employees with the necessary skills, knowledge, and mindset to adapt to new processes, technologies, or organizational structures.
Mızrak, Filiz, Çaylan, Şenay
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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