Results 81 to 90 of about 852,934 (330)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hubungan Budaya Organisasi dan Komitmen Organisasional pada Kinerja Karyawan

Trikonomika, 2014
The purpose of the research was to find out the relationship of organizational culture and organizational commitment with employee performance. The population in this research were 51 employees at PT Tirta Sarana Sukses.
Jessica Clairine Tanuwibowo, Eddy M. Sutanto   +1 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Relationships among leadership, organizational commitment, and ocb in uruguayan health institutions [PDF]

We develop and test a model that relates leadership behaviors, organizational commitment, and organizational citizenship behaviors (OCBs). We test the model using structural equations with a sample of 116 doctors from Uruguay.
Cardona, Pablo, Lagomarsino, Raul
core  

Proactive and politically skilled professionals: What is the relationship with affective occupational commitment? [PDF]

, 2013
The aim of this study is to extend research on employee affective commitment in three ways: (1) instead of organizational commitment the focus is on occupational commitment; (2) the role of proactive personality on affective occupational commitment is ...
A Cohen, A Cohen, A Cohen, A Cooper-Hakim, A Vos De, Amna Yousaf, AP Brief, B Erdogan, BL Kirkman, C Handy, C Vandenberghe, D Ahlstrom, D Brown, D Chan, D Hall, D Katz, D Watson, DA Major, G Blau, G Hofstede, G Hofstede, GR Ferris, H Mintzberg, H Mintzberg, Helen Shipton, J Erdheim, J Netter, JA Thompson, JB Thatcher, JD Kammeyer-Mueller, JE Mathieu, JH Greenhaus, JM Crant, JM Crant, JM Crant, JM Crant, JP Curry, JP Meyer, JP Meyer, K Lee, K Matzler, Karin Sanders, KS Law, L Dyne Van, L Ji, LS Aiken, LW Porter, NA Bowling, NJ Allen, P Harvey, P Morrow, P Spector, PC Morrow, PL Perrewe, PM Podsakoff, R Johnson, RJ Vandenberg, RM Baron, RM Steers, RP Settoon, S Chatterjee, S Nollen, SE Seibert, SE Seibert, SK Parker, SK Parker, SM Colarelli, SP Brown, SS Kohler, T Fang, TA Judge, UE Gattiker, Y Li   +72 more
core   +4 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Impact of organizational climate on organizational commitment and perceived organizational performance: empirical evidence from public hospitals

BMC Health Services Research, 2018
Background Extant literature suggested that positive organizational climate leads to higher levels of organizational commitment, which is an important concept in terms of employee attitudes, likewise, the concept of perceived organizational performance ...
Aysen Berberoglu
doaj   +1 more source

Pengaruh Budaya Organisasional dan Motvasi terhadap Kinerja Guru Dimediasi Komitmen Organisasional (Studi pada Guru SD di Upt Dindikbud Doro Kabupaten Pekalongan) [PDF]

, 2015
Studies in this study about the influence of organizational culture, motivation and organizational commitment on teacher performance. The issues raised in this study were: (1) examine the influence of organizational culture, motivation and organizational
Supardi, 1. 5. (13)
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Work Attitude, Organizational Commitment and Emotional Intelligence of Malaysian Vocational College Teachers

, 2021
Rosnee Ahad, Mohamad Zaid Mustafa, Suhaimi Mohamad, Nur Hanim Saadah Abdullah, Mohd Norazmi Nordin, Universiti Tun Hussein Onn Malaysia, Parit Raja, 86400, MALAYSIA, Nur Hanim Saadah Abdullah, Universiti Tun Hussein Onn Malaysia, Parit Raja, 86400, MALAYSIA, Mohd Norazmi Nordin, Universiti Tun Hussein Onn Malaysia, Parit Raja, 86400, MALAYSIA   +9 more
openalex   +2 more sources