Results 51 to 60 of about 2,720 (258)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Toxic Corporate Culture: Assessing Organizational Processes of Deviancy [PDF]
Administrative Sciences, 2018 There is widespread recognition that organizational culture matters in corporations involved in systemic crime and wrongdoing. However, we know far less about how to assess and alter toxic elements within a corporate culture. The present paper draws on management science, anthropology, sociology of law, criminology, and social psychology to explain ...
van Rooij, B., Fine, A.
openaire +5 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The relationship between person-organization fit, organizational identification and work outcomes
Journal of Business Economics and Management, 2014 The purpose of this research is to analyse the relationship of person-organization fit in hotels through organizational identification, job performance, production deviance behavior, and the intention to remain.
Mahmut Demir +2 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Now You Do It, Now You Don’t: The Mixed Blessing of Creative Deviance as a Prosocial Behavior
Frontiers in Psychology, 2020 Creative deviance, the act of developing an idea by an employee even when it was banned by the manager, is a novel and interesting construct that can bring both positive and negative outcomes to organizations.
Jigyashu Shukla, Ronit Kark, Ronit Kark
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Team Focus in Focus: Its Implications for Real Teams and Their Members
Journal of Work and Organizational Psychology, 2019 We develop and test a cross-level model of team focus on positive and negative discretionary team member behaviors. Using data collected from 405 team members across 76 teams and 15 organizations, we find that team focus is positively associated with ...
Kevin S. Cruz, Jonathan Pinto
doaj +1 more source
Effect of despotic leadership on organizational deviance: The mediating role of Psychological Contract Breach and moderating role of moral identity [PDF]
Problems and Perspectives in ManagementType of the article: Research Article Abstract Drawing on social exchange theory, this study aims to expand the literature on despotic leadership as a prominent indicator of organizational deviance using a moderate mediation framework.
Hassan Al-Kashab +2 more
doaj +1 more source