Results 141 to 150 of about 783,880 (299)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Unpacking the dynamics of authentic leadership in shaping employee-felt obligation through moderated mediation

Discover Psychology
Despite considerable research on authentic leadership’s influence on employee outcomes like organizational identification and citizenship behaviors, its impact on felt obligation—a critical yet underexplored motivational construct—remains insufficiently ...
Sina Eslamdoust, Tahmineh Borhani, Rasam Dorri, Minoo Karandish   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

High-performance work practices and employee wellbeing: organizational identification as a mediator. [PDF]

Front Psychol, 2023
Salin D, Stride C, Smith S, Santokhie S.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The impact of authentic leadership on frontline health workers’ safety performance

Discover Public Health
This study investigated the impact of authentic leadership on frontline healthcare workers’ safety performance during the COVID-19 pandemic, with organizational identification examined as a mediator.
Francisca Arboh, Samuel Atingabili, Prince Ewudzie Quansah, Stephen Addai-Dansoh, Esther Agyeiwaa Owusu   +4 more
doaj   +1 more source

Identity leadership predicts career calling via organizational identification: evidence from Iran, Italy, and Germany and the moderating role of ambivalent identification

Frontiers in Organizational Psychology
IntroductionThis study examines the role of identity leadership in shaping employees' career calling and work-related attitudes across cultural contexts. Drawing on the Social Identity Approach and research on calling, we propose a serial mediation model
Mahtab Fardi, Benedikt E. Kratzer, Lorenzo Avanzi, Rolf van Dick   +3 more
doaj   +1 more source

Can Organizational Identification Weaken the Negative Effects of Customer Bullying?-Testing the Moderating Effect of Organizational Identification. [PDF]

Front Psychol, 2022
Huang H, Yu S, Peng P.
europepmc   +1 more source

Organizational Change and the Identity Cycle: Understanding the Effect of Change on Individual Attitudes and Behaviors Through a Combined Social Identity Theory/Identity Theory Perspective [PDF]

, 1994
The study of roles and role behavior is particularly relevant today as individuals acquire more roles in the complexity of the 1990s. One environment that has been significantly prone to change is the workplace, where multiple committees, teams, and ...
Cable, Daniel M., Welbourne, Theresa M.   +1 more
core   +2 more sources