Results 61 to 70 of about 417,326 (307)

Correlations of Resource Bricolage and Exaptation With Low-Cost Breakthrough Innovations: Moderating Effect of Organizational Agility

Frontiers in Psychology, 2022
The mechanism influencing resource bricolage driving low-cost breakthrough innovations remains unclear. By introducing exaptation and organizational agility, this study creates a regulated mediation model, explores effects of resource bricolage on low ...
Chaoyong Tang, Yongzhi Shi, Ruilin Cai
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Do organizational incentives spur innovation? [PDF]

BAR - Brazilian Administration Review, 2012
To date, we have only partially begun to develop an understanding of the channels through which innovation is facilitated within organizations. Although talented individuals are pivotal to supporting knowledge accumulation and renewal, they may be more willing to contribute new ideas if they expect to reap some of the gains that these ideas generate ...
Barros, Henrique M., Lazzarini, Sergio G.   +1 more
openaire   +4 more sources

Effects of innovation types on firm performance [PDF]

, 2009
Innovation is broadly seen as an essential component of competitiveness, embedded in the organizational structures, processes, products, and services within a firm.
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy, Gunduz, Ulusoy, Gündüz   +7 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Organizational climate for innovation and organizational performance: The mediating effect of innovative work behavior [PDF]

Journal of Vocational Behavior, 2017
Despite a plethora of literature on organizational climate for innovation and the persuasive arguments establishing its link to organizational performance, few studies hitherto have explored innovative work behavior of managers. Specifically, limited attention has been paid to explaining how organizations perceive the importance of stimulating ...
Shanker, R, Bhanugopan, R, van der Heijden, BIJM, Farrell, Mark   +3 more
openaire   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Relationship between Organizational Intelligence and Innovations: Case of Lithuanian Sports Federations

Baltic Journal of Sport and Health Sciences, 2018
Background.  Sports  organizations  exist  to  perform  tasks  that  can  only  be  executed  through  cooperative effort, and sports management is responsible for the performance and success of these organizations.
Inga Staškevičiūtė Butienė, Irena Valantinė, Edvinas Eimontas   +2 more
doaj   +1 more source

Network Effects on Radical Innovation and Financial Performance: An Open-mindedness Approach [PDF]

BAR: Brazilian Administration Review, 2016
This study examines how companies can achieve high performance through certain organizational behaviors (open-mindedness and social networks) and innovation.
Marcelo Gattermann Perin, Cláudio Hoffmann Sampaio, Daniel Jiménez-Jiménez, Juan Garcia Cegarra-Navarro   +3 more
doaj   +1 more source