Results 81 to 90 of about 1,596,918 (298)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Electronic services as organizational innovations [PDF]

, 2013
In public organization transition from traditional model of service delivery to electronic services is a premise to the implementation of organizational innovations.
Jastrzębska, Karolina
core  

Different Forms of Innovations: Meta-Analysis of the Organizational Innovation Surveys

Управленческое консультирование, 2018
In article on the basis of official data of state statistics analyzes results of the surveys, which were conducted in Europe, in order to investigate the innovation activity of companies. Focuses on organizational innovations.
Lidiya Nikolaevna Melnikova
doaj  

The importance of innovation in the Czech and Slovak spa industry: the COVID-19 era and beyond

Sport i Turystyka
This study aims to analyze the scope, structure, and perceived benefits of innovations implemented by spa businesses in the Czech Republic and the Slovak Republic over a period spanning the pre-COVID-19, pandemic, and post-pandemic phases (2018–2022 ...
Josef Pátek, Jiří Zelený, Lucie Plzáková, Petr Studnička   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Motivating Organizational Search [PDF]

This paper investigates the value of high-powered incentives for motivating search for novelty in business organizations. While organizational search critically depends on the individual efforts of employees, motivating search effort is challenged by ...
Nils Stieglitz, Oliver Baumann
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Valuable innovations out of nonsense? Expansive organizational learning and transformative agency in the Mann Gulch disaster and in the Finnish homelessness strategy

Teoria e Prática em Administração, 2018
The study explores the role nonsense may play when innovations are conceived and how innovations out of nonsense possibly inform processes of organizational learning.
Annalisa Sannino, Yrjö Engeström
doaj   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Process Moves in The Intra-organizational Diffusion of Knowledge Management: Preliminary Findings from A Study on CKO Effectiveness [PDF]

The existing literature on Chief Knowledge Officers (CKOs) focuses on individual characteristics and organizational context but fails to convincingly address the issue of process dynamics in terms of effective and ineffective CKO moves and strategies. In
Charles-Clemens Rüling, Steffen Raub
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