Results 71 to 80 of about 1,596,918 (298)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Realizing Innovations in Service Firms: new organizational forms and supporting processes [PDF]
This paper describes a number of innovation forms that are of special relevance to firms in the service industry. Not only technological innovations but also organizational innovations have been distinguished.
Elfring, T., Aa, W. van der
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Scholar-based Innovations in Publishing [PDF]
, 2003 In recent years, a number of innovations have emerged that seek to provide sustainable alternatives to the predominant publishing paradigm. In this presentation, a variety of initiatives that exploit the inherent potential of the Web and other digital ...
McKiernan, Gerry
core +1 more source
THE RELATIONSHIP OF INNOVATION WITH ORGANIZATIONAL PERFORMANCE
International Journal of Research -GRANTHAALAYAH, 2017 This research study investigates the relationship of innovation with organizational performance of the telecommunication sector. The independent variables are process innovation, product innovation and organizational innovation as an organizational culture as moderating variable. The research is survey research in which questionnaire is administered to
Abdul karim Suhag +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Synergistic effects of organizational innovation practices and firm performance [PDF]
Organizational innovation has been shown to be favourable for technological innovation. However, the question of which organizational practices should be combined ? and thus of their compatibility ? remains unanswered. We here empirically investigate the
NGUYEN-VAN Phu +2 more
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Inter-Organizational Innovations for Port Security [PDF]
, 2010 This report describes and analyzes inter-organizational innovations in port security. Inter-organizational collaboration has become increasingly recognized as a critical element of success in many complex and dynamic environments, including homeland ...
Hocevar, Susan Page
core +2 more sources