Results 91 to 100 of about 1,154,495 (307)

Missing Links: Referrer Behavior and Job Segregation [PDF]

open access: yes, 2013
The importance of networks in labor markets is well-known, and their job segregating effects in organizations taken as granted. Conventional wisdom attributes this segregation to the homophilous nature of contact networks, and leaves little role for ...
Fernandez, Roberto, Rubineau, Brian
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

How to Use Models of Organizational Decision Making?

open access: yesAnnals of Business Administrative Science, 2014
When explaining organizational decision making, there is often an implicit assumption that an organization makes decisions based on rational principles. However, there are situations in which rationality cannot explain all phenomena.
Kenichi KUWASHIMA
doaj   +1 more source

Reflections of Practicing School Principals on Ethical Leadership and Decision-Making: Confronting Social Injustice [PDF]

open access: yes, 2015
The study objective was to identify leadership dilemmas of practicing school administrators and their own codes of ethics to inform understandings of ethical decision-making. Ethical decision-making underpins leadership practice, theory, and preparation.
Gardiner, Mary E., Tenuto, Penny L.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Organizational models for the flexible management of hospitals

open access: yesTechne, 2015
Italian hospitals are adopting the private-sector approach, which means that they tend to work towards improving their service offerings and rationalizing health-care spending by introducing new organizational models for the management and control of ...
Maria Luisa Del Gatto   +2 more
doaj   +1 more source

Organizational learning: Where do we stand? Where do we want to go? [PDF]

open access: yes
The field of organizational learning has developed dynamically but is not ready for closure. This article reviews the cultural contexts in which research on organizational learning has been conducted since the 1960s, and the intellectual traditions that ...
Antal, Ariane Berthoin, Dierkes, Meinolf
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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