Results 31 to 40 of about 166,775,727 (245)

Identifying agroecological transition pathways based on the Global Approach to Agricultural Systems: the case of family livestock farmers in northern Uruguay

Agrociencia Uruguay, 2023
Agroecology represents one of the main alternatives to production models generated by the green revolution, both in Uruguay and other countries. It appears as a response to climate change, biodiversity management, nature resource restoration, and, more ...
Inés Ferreira Rivaben, Virginia Rossi, Mercedes Figari, Eduardo Chia   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Innovation and knowledge in sustainable supply chains: how ethical climate and training reduce greenwashing risk [PDF]

International Journal of Climate Change Strategies and Management
PurposeThe purpose of this study is to analyze how an organization’s ethical climate and the quality of its sustainability training initiatives contribute to innovation and knowledge while helping to minimize greenwashing risk in production-based supply ...
Waqar Akbar, Rana Salman Anwar, Rizwan Raheem Ahmed, Dalia Streimikiene, Ahmad Naim Che Pee, Justas Streimikis   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Decoding innovation configurations for agribusiness performance: Indonesian evidence

Cogent Business & Management
Literature on agribusiness innovation in the Global South still examines product, process, marketing, and organizational innovations as isolated domains, thereby overlooking how their complementarities shape agribusiness performance within resource ...
Moh. Solehatul Mustofa, Kemal Budi Mulyono, Nurul Fatimah   +2 more
doaj   +1 more source

Business Model Innovation: Strategic Expansion of German Small and Medium Wineries into Hospitality and Tourism

Administrative Sciences, 2021
This article provides insights into the modalities of business-model change and innovation. On the basis of an analysis of empirical data of small and medium enterprises, a transition from wine production centrism to its expanded use in hospitality and ...
Marc Dressler, Ivan Paunovíc
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Characterizing and comparing innovation systems by different ‘modes’ of knowledge production: A proximity approach [PDF]

, 2015
Though the concept of innovation systems has become influential in both academia and policymaking, an analytical approach to understanding innovation systems is still lacking. In particular, there is no analytical framework to measure `Mode 1?
Nomaler, ZO Önder, Frenken, K., Hardeman, Sjoerd, Ter Wal, Anne L. J., Wal, ALJ ter, Frenken, K Koen, Nomaler, Z.O., Hardeman, S Sjoerd, Frenken, Koen, Wal, ter, A.L.J, Nomaler, Önder, Hardeman, S., Innovation Studies, Dynamics of Innovation Systems   +13 more
core   +3 more sources

Product, Process and Organizational Innovation: Drivers, Complementarity and Productivity Effects [PDF]

We propose a model where both R&D and ICT investment feed into a system of three innovation output equations (product, process and organizational innovation), which ultimately feeds into a productivity equation.
Wladimir Raymond, Michael Polder, George van Leeuwen, Pierre Mohnen   +3 more
core   +2 more sources