Results 51 to 60 of about 366,460 (277)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Business Model Innovation: Strategic Expansion of German Small and Medium Wineries into Hospitality and Tourism

Administrative Sciences, 2021
This article provides insights into the modalities of business-model change and innovation. On the basis of an analysis of empirical data of small and medium enterprises, a transition from wine production centrism to its expanded use in hospitality and ...
Marc Dressler, Ivan Paunovíc
doaj   +1 more source

Innovation determinants in manufacturing firms [PDF]

, 2009
In this paper the findings of an empirical study concerning the innovation determinants in manufacturing firms is presented. The empirical study covers 184 manufacturing firms located in the Northern Marmara region of Turkey.
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy, Gunduz, Ulusoy, Gündüz   +7 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Process of formation and implementation of polygraphic enterprises’ marketing innovation policy

Вісник Житомирського державного технологічного університету: Серія: економіка, управління та адміністрування, 2019
The paper proves that the marketing innovative policy of the enterprise promotes the interaction of scientific and technical, marketing, production, social, organizational and economic activities in the process of creation and implementation of ...
K.S. Shaban
doaj   +1 more source

THE ROLE OF INNOVATION CLUSTERS FOR THE SUSTAINABLE DEVELOPMENT OF THE REGION

Baltic Journal of Economic Studies, 2023
The article considers the directions of intensification of the processes of clustering in the regions of Ukraine. Based on the analysis of the experience of clustering is proposed zoning, taking into account the collisions of national business and ...
Olga Kudrina, Yuliia Klius, Yevhen Ivchenko   +2 more
doaj   +1 more source

How innovative are UK firms? Evidence from the Fourth UK Community Innovation Survey on synergies between technological and organizational innovations [PDF]

, 2010
Using data from the Fourth UK Community Innovation Survey this paper explores the diffusion of a range of innovative activities (encompassing process, product, machinery, marketing, organization, management and strategic innovations) across 16,383 ...
Arora, Arora, Bartel, Battisti, Berman, Black, Bloom, Bresnahan, Brynjolfsson, Cappelli, Caroli, Cohen, Colombo, Colombo, Edwards, Finegold, Geroski, Hannah, Ichniowski, Ichniowski, Ireland, Karshenas, Leseure, Little, Mansfield, Milgrom, Milgrom, Noteboom, O'Mahony, Perrow, Ruigrok, Saloner, Stoneman, Stoneman, Stoneman, Whittington, Åstebro, Åstebro   +37 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Non-standard innovation: an attempt to (re)think innovation

Sustainability: Science, Practice, & Policy
In the face of ecological degradation, ethical concerns, and the growing instrumentalization of innovation by capitalist and managerial logics, this article proposes a radical rethinking of innovation. Drawing on Laruelle’s “non-philosophy,” later termed
Xavier Pavie
doaj   +1 more source

What are the determinants leading to innovation in manufacturing firms [PDF]

, 2013
In this paper, a comprehensive model of innovation determinants is analyzed based on empirical data gathered from 184 manufacturing firms located in the Northern Marmara region in Turkey.
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy, Gunduz, Ulusoy, Gündüz   +7 more
core