Results 41 to 50 of about 364,869 (274)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Agrociencia Uruguay, 2023 Agroecology represents one of the main alternatives to production models generated by the green revolution, both in Uruguay and other countries. It appears as a response to climate change, biodiversity management, nature resource restoration, and, more ...
Inés Ferreira Rivaben +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Absorptive capacity and relationship learning mechanisms as complementary drivers of green innovation performance [PDF]
, 2018 This paper aims to explore in depth how internal and external knowledge-based drivers actually affect the firms\u2019 green innovation performance. Subsequently, this study analyzes the relationships between absorptive capacity (internal knowledge-based ...
Albort-Morant, Gema +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Administrative Sciences, 2021 This article provides insights into the modalities of business-model change and innovation. On the basis of an analysis of empirical data of small and medium enterprises, a transition from wine production centrism to its expanded use in hospitality and ...
Marc Dressler, Ivan Paunovíc
doaj +1 more source
Do product innovation-related activities affect downsizing decisions? An organizational efficiency perspective [PDF]
, 2017 Firms’ innovation strategy typically involves the need to shape organizational changes within work structures and routines, even those concerning employee downsizing decisions.
Estrella Ramón, Antonia +3 more
core
Experimental study and numerical modelling of woven fabric kenaf fiber composites hybrid adhesively bonded-bolted joints [PDF]
, 2018 Couple with natural fiber composite parts, hybrid joints provide better joint strength than using separate joints. There are limited studies on structures response and strength prediction work on hybrid joints that limits its applicability.
Lee, Sim Yee
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source