Results 61 to 70 of about 91,350 (314)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Innovative exploration of spatial collaborative governance in the Shanghai Metropolitan Area
Frontiers of Urban and Rural PlanningUnder the requirements of modernized spatial governance and the national strategy for the integrated development of the Yangtze River Delta, the Shanghai Metropolitan Area has taken the lead in exploring collaborative governance in regional spatial ...
Juan Sun, Xuan Ma, zhenguang Zhang
doaj +1 more source
A SZERVEZETFEJLESZTÉS SZÜKSÉGESSÉGE AZ ISKOLÁKBAN [PDF]
PedActa, 2016 The authors’ basic assumption is that continuous changes in society affect schools and therefore it is necessary to systematically develop schools as organizations.
Albert-Lőrincz Enikő +3 more
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INTERNAL PLANNING AND ORGANIZATION OF INNOVATIONS IN ENTERPRISE ECONOMIC MANAGEMENT
, 2023 Liudmyla Dashutina, Тянь Сюй
openalex +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Peculiarities of organizational and technological approaches to the post-war restoration of infrastructural objects in Ukraine [PDF]
E3S Web of ConferencesAs a result of russia’s insidious war against Ukraine, thousands of infrastructure facilities and energetical objects were destroyed or damaged. We are sure, Ukraine will win this war.
Savytskyi Mykola +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Journal of Industrial Design and Engineering Graphics, 2017 This article aims at drawing a design plan of organizational identity to the Engineering Graphics and Industrial Design Department, University Polytechnica of Bucharest.
CREŢU Ionuţ
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source