Results 71 to 80 of about 8,514,639 (349)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

You are entitled to access the full text of this document A decision science approach to redesigning organizational structure: empirical insights from business process mapping and strategy alignment [PDF]

Decision Science Letters
This study investigates the complex relationship between organizational structure and strategic planning, emphasizing how business process mapping contributes to decision-making frameworks in organizational design.
Martinus Tukiran, Nurul Ainu Sofi, Winnie Pratiwi Anas   +2 more
doaj   +1 more source

Circular 60 [PDF]

, 1987
The University o f Alaska-Fairbanks reindeer program has existed under its current organizational framework since 1981. Program guidance across the three functions o f research, extension, and instruction continues to meet with support both internal ...
Epps, Alan C.
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

THE ROLE AND IMPORTANCE OF THE STRATEGIC PLANNING IN BANK MARKETING [PDF]

The paper aims to highlight the strategic planning role and place in bank marketing, define the concepts of strategic planning and marketing planning and the tactical planning, marketing plan and marketing program.
PISTOL , Gheorghe
core  

PENGARUH KEPEMIMPINAN PARTISIPATIF DAN KOMITMEN ORGANISASI TERHADAP EFEKTIFITAS IMPLEMENTASI RENCANA STRATEJIK PADA MADRASAH ALIYAH DI KABUPATEN SUKABUMI JAWA BARAT [PDF]

, 2014
Madrasah harus memiliki sebuah rencana stratejik (renstra) yang mapan, yang didasarkan pada analisis situasi internal dan eksternal, yang dapat mereposisi setiap unsur diluar organisasi yang berpengaruh terhadap implementasinya seperti kepemimpinan ...
Lestari, Raden Andriani
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

SUCCESSFUL SUCCESSION: THE ROLE OF THE ENVIRONMENT AND THE SUCCESSION PLAN [PDF]

RAE: Revista de Administração de Empresas, 2021
Succession literature remains non-cumulative and disjointed, and studies are only just appearing that offer an overall view of the factors that make the succession process a success.
Guadalupe Manzano García, Juan-Carlos Ayala-Calvo, Alexandre José Schumacher   +2 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source