Results 91 to 100 of about 4,312,287 (298)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Administrative SciencesPerformance management is critical for aligning human capital with organizational strategy, particularly in the increasingly competitive service sector.
Maria C Tavares, Mariana Vaz
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Journal of Applied Science and EngineeringThe corporate innovation landscape has dramatically transformed by the fast adoption of digital technologies, especially the likes of AI and cloud computing.
Likang Qin, Ying Dong, Zeyu Li
doaj +1 more source
Organizational Culture and Its Implementation in the Choice of Strategic Option - Case Study Montenegro [PDF]
Expert Journal of Business and Management, 2014 The topic of this paper is to examine the influence of organizational culture on determination and implementation of the appropriate strategy within the company.
Gordana NIKČEVIĆ
doaj
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Marketing Strategy and Organizational Culture: A Conceptual and Empirical Integration
Marketing Management Journal, 1999 In recent years there has been a growing interest in the concept of organizational culture. While a few of these studies have explicitly discussed the relationship between organizational culture and strategy, to date no study has been published which ...
THOMAS L. BAKER +2 more
doaj +1 more source
INNOVATION STRATEGIES AND ORGANIZATIONAL COMPETITIVENESS
DIEM : Dubrovnik International Economic MeetingOrganizational innovation is a crucial factor for the competitiveness and performance of a company as it enables adaptability, efficiency and long-term market success. The paper examines the role of innovation strategies in shaping the competitive position of firms, focusing on organizational innovation, structural change and strategic flexibility.
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source