Results 81 to 90 of about 178,781 (311)

The Organizational Fitness Navigator: Creating and Measuring Organizational Fitness for Fast-Paced Transformation [PDF]

In the fast-changing environment of today dynamic capabilities to manage organizational transformation are regarded as crucial for business survival and improved performance.
Voelpel, Sven C., Leibold, Marius, Mahmoud, Khalid M.   +2 more
core  

Effects of strategic leadership, organizational innovativeness and information technology capability on effective strategy implementation [PDF]

, 2016
The paper examined the role of strategic leadership, organizational innovativeness, information technology capability on strategy implementation in tertiary institutions situated at Kaduna state, Nigeria.
Palladan, Ahmad Aliyu, Abdul Kadir, Kadzrina, Yen, Wan Chong   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Inertia and Incentives: Bridging Organizational Economics and Organizational Theory [PDF]

Organizational theorists have long acknowledged the importance of the formal and informal incentives facing a firm%u2019s employees, stressing that the political economy of a firm plays a major role in shaping organizational life and firm behavior.
Rebecca Henderson, Sarah Kaplan
core  

Dinamización de la gestión ambiental con enfoque epidemiológico en la Empresa de Torcido de Tabaco Holguín

Revista Cubana de Higiene y Epidemiología
La gestión ambiental empresarial es el factor determinante para una efectiva gestión epidemiológica desde la concepción de la estrategia empresarial, y para su dinamización se utiliza un modelo teórico sustentado en un procedimiento, enriquecido por la ...
Caridad Evangelina Mastrapa Reyes, Carlos Manuel Vilariño Corella, Rubén Cañedo Andalia   +2 more
doaj  

Adaptive strategies and sustainable investments: navigating organizations through a VUCA environment in and after COVID-19

Technological and Economic Development of Economy
This study delves into the resilience and adaptability of employees within the volatile, uncertain, complex, and ambiguous (VUCA) business environment, examining their readiness to manage effectively and the organizational agility in navigating change ...
Mihaela Minciu, Cristina Veith, Razvan Catalin Dobrea, Vladimir-Codrin Ionescu   +3 more
doaj   +1 more source

Testing for strategy-structure fit and its importance for performance

Management : Journal of Contemporary Management Issues, 2017
Understanding different organizational elements, their mutual influence and creating congruence among them has been recognized as an important determinant of organizational performance.
Ana Aleksić, Sanda Rašić Jelavić
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

INNOVATION STRATEGIES AND ORGANIZATIONAL COMPETITIVENESS

DIEM : Dubrovnik International Economic Meeting
Organizational innovation is a crucial factor for the competitiveness and performance of a company as it enables adaptability, efficiency and long-term market success. The paper examines the role of innovation strategies in shaping the competitive position of firms, focusing on organizational innovation, structural change and strategic flexibility.
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source