Results 71 to 80 of about 114,995 (264)

Adaptive strategies and sustainable investments: navigating organizations through a VUCA environment in and after COVID-19

Technological and Economic Development of Economy
This study delves into the resilience and adaptability of employees within the volatile, uncertain, complex, and ambiguous (VUCA) business environment, examining their readiness to manage effectively and the organizational agility in navigating change ...
Mihaela Minciu, Cristina Veith, Razvan Catalin Dobrea, Vladimir-Codrin Ionescu   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Testing for strategy-structure fit and its importance for performance

Management : Journal of Contemporary Management Issues, 2017
Understanding different organizational elements, their mutual influence and creating congruence among them has been recognized as an important determinant of organizational performance.
Ana Aleksić, Sanda Rašić Jelavić
doaj   +1 more source

INNOVATION STRATEGIES AND ORGANIZATIONAL COMPETITIVENESS

DIEM : Dubrovnik International Economic Meeting
Organizational innovation is a crucial factor for the competitiveness and performance of a company as it enables adaptability, efficiency and long-term market success. The paper examines the role of innovation strategies in shaping the competitive position of firms, focusing on organizational innovation, structural change and strategic flexibility.
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Staking out the Stakeholders: Using NIST’s Research Data Framework Within a Public University System

Journal of eScience Librarianship
Purpose: This article first introduces and contextualizes the National Institute of Standards and Technology (NIST) Research Data Framework (RDaF) and then explores its application in a local context.
Andrea Medina-Smith, Bridget Almas, Catherine Stollar Peters, Emily Kilcer, Jessica A. Koos   +4 more
doaj   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Rethinking Performance Evaluation: Strategic Alignment in the Service Sector Through a Case-Based Framework

Administrative Sciences
Performance management is critical for aligning human capital with organizational strategy, particularly in the increasingly competitive service sector.
Maria C Tavares, Mariana Vaz
doaj   +1 more source