Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Improving Organizations by Replacing the "Mechanical" Model with the "Organic" one [PDF]
Organizations are currently viewed as artificial structures. However, in our opinion, organizations seem to match a biological structure much better. This paper explores this new approach with some interesting conclusions and results: organizations aim ...
George MOLDOVEANU +2 more
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Managing complexity in a distributed digital library [PDF]
, 1999 As the capabilities of distributed digital libraries increase, managing organizational and software complexity becomes a key issue. How can collections and indexes be updated without impacting queries currently in progress?
Apperley, Mark +5 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
THE ANALYSIS OF STRUCTURAL CONFIGURATIONS FOR IMPLEMENTING COMPETITIVE STRATEGIES
Сучасний стан наукових досліджень та технологій в промисловості, 2017 Among the directions of increasing the competitiveness of enterprises, the development of an adequate organizational structure is of primary importance.
Galyna Nazarova, Nikita Nazarov
doaj +1 more source
Distance, Bank Organizational Structure and Credit [PDF]
We survey the extant literature on the effects of both a bank’s organizational structure and the physical distance separating it from the lender on lending decisions.
Cerqueiro, G.M. +2 more
core +1 more source
Collaboration and Connection: How Foundations Partner Effectively to Address Their Community's Information Needs [PDF]
, 2012 Offers examples and tips for partnering with the public, private, and nonprofit sectors on community news and information projects, including finding the right partner by assessing organizational capacity, community assets, compatibility, and ...
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The Impact of Organizational Structure and Lending Technology on Banking Competition [PDF]
Recent theoretical models argue that a bank’s organizational structure reflects its lending technology. A hierarchically organized bank will employ mainly hard information, whereas a decentralized bank will rely more on soft information.
Degryse, H.A., Laeven, L., Ongena, S.
core +4 more sources
MODERNIZATION OF THE ORGANIZATIONAL STRUCTURE OF MANUFACTURING ENTERPRISES
Дискурс, 2018 Currently, in many industrial enterprises the organizational structure of management is formed empirically and is based on formalization and documentation of links established between the units and the set of functions performed by them.
I. G. Fomina
doaj +1 more source