Results 41 to 50 of about 35,025 (266)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Role of Capacity in Understanding Organizational Change in National Sports Federations

Organizacijų Vadyba: Sisteminiai Tyrimai, 2019
The aim of this paper is to present an overview of selected organizational theories pertaining to the process of organizational change. The emphasis is made on organizational capacity outlining its relevance in the context of understanding the changes ...
Gobikas Mindaugas, Čingienė Vilma
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Analyzing the Reasons for Not Using the Value Analysis and Lean Approach (case study) [PDF]

مدیریت بهره وری, 2009
The aim of this article is to investigate the reasons for un- application of value analysis and pure thinking in auto-part manufacturing companies in small industries and industrial towns in East Azerbaijan and to determine the intra-organizational and ...
Houshang Taghizadeh, Mehrdad Mohammad pour Shattery   +1 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

High-performance human resource practices, organizational identification and employee commitment: the moderating role of organizational culture

Frontiers in Psychology
PurposeDrawing on social exchange and social identity theories, this study examines the mediating role of organizational identification on the relationship between high-performance human resource practices (HPHRPs) and employee commitment.
Yifan Yang, Ahmed Mohammed Sayed Mostafa, Ahmed Mohammed Sayed Mostafa   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Analyzing and Mapping the Leadership Literature and Its Organizational Implications: An Integrative Analysis

Administrative Sciences
With an emphasis on organizational outcomes and emerging leadership approaches, this review assessed the major contributions of leadership research over the past two decades and explored the evolution of theoretical developments in the field.
Hale Alan, Neslihan Onur
doaj   +1 more source

Organizational Health Literacy: Review of Theories, Frameworks, Guides, and Implementation Issues

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2018
Organizational health literacy is described as an organization-wide effort to transform organization and delivery of care and services to make it easier for people to navigate, understand, and use information and services to take care of their health ...
Elina Farmanova PhD, Luc Bonneville PhD, Louise Bouchard PhD   +2 more
doaj   +1 more source