Results 61 to 70 of about 691,724 (295)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Organizational Health Literacy: Review of Theories, Frameworks, Guides, and Implementation Issues

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2018
Organizational health literacy is described as an organization-wide effort to transform organization and delivery of care and services to make it easier for people to navigate, understand, and use information and services to take care of their health ...
Elina Farmanova PhD, Luc Bonneville PhD, Louise Bouchard PhD   +2 more
doaj   +1 more source

Organizational Culture and Ethical Decision-Making During Major Crises [PDF]

, 2019
By integrating various behavioral and ethical theories, such as Organizational Culture and the Social Construction of Knowledge, this research argues that emergency micro-cultures often emerge in times of crisis.
Mumley, William E
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

High-performance human resource practices, organizational identification and employee commitment: the moderating role of organizational culture

Frontiers in Psychology
PurposeDrawing on social exchange and social identity theories, this study examines the mediating role of organizational identification on the relationship between high-performance human resource practices (HPHRPs) and employee commitment.
Yifan Yang, Ahmed Mohammed Sayed Mostafa, Ahmed Mohammed Sayed Mostafa   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Analyzing and Mapping the Leadership Literature and Its Organizational Implications: An Integrative Analysis

Administrative Sciences
With an emphasis on organizational outcomes and emerging leadership approaches, this review assessed the major contributions of leadership research over the past two decades and explored the evolution of theoretical developments in the field.
Hale Alan, Neslihan Onur
doaj   +1 more source

Management ideologies and organizational spirituality: a typology [PDF]

The topic of spirituality is gaining an increasing visibility in organization studies. It is our contention that every theory of organization is a theory of organizational spirituality.
Cunha, Miguel Pina e, D'Oliveira, Teresa, Rego, Armenio   +2 more
core  

The geography of strain: organizational resilience as a function of intergroup relations [PDF]

, 2017
Organizational resilience is an organization’s ability to absorb strain and preserve or improve functioning, despite the presence of adversity.
Barton, M., Fisher, C., Heaphy, E., Kahn, W. A., Reid, E., Rouse, E.   +5 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source