Results 71 to 80 of about 35,025 (266)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

The analysis and investigation of axiological presuppositions of organizational justice [PDF]

اسلام و مدیریت
This paper aimed at discovering, investigation and analysis of axiological foundations of organizational justice from the perspective of Islamic ethics. The existing disagreement between realists and anti-realists on the values has been known as the most
doaj  

A Review of Leadership Theories in Healthcare

Journal of Pharmacy and Bioallied Sciences
Leadership plays a critical role in shaping the dynamics, quality, and outcomes of healthcare systems. This review explores the evolution and application of leadership theories within the healthcare sector, highlighting their relevance in addressing ...
Farha Rizwan Sikalgar, Deepak Bangera, Manasvi P Kumar, Bhuvaneshwari, Yuvaraj Paul, Shrikanth Muralidharan   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Green Supply Chain Practices: a comprehensive and theoretically multidimensional framework for categorization

Production
Paper aims The main objective of this work is to integrate a typology of green supply chain management practices with organizational theories. Originality We provide a comprehensive typology of GSCM practices based on empirical evidence and conceptual ...
Jairo José Assumpção, Lucila Maria de Souza Campos, Ana Beatriz Lopes de Sousa Jabbour, Charbel José Chiappetta Jabbour, Diego Alfonso Vazquez-Brust   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Trust as the Foundation of Effective Management: Between Control and Support in the Context of Douglas McGregor’s Theories X and Y

Путеводитель предпринимателя
The article presents a comprehensive analysis of the applicability of Douglas McGregor’s managerial assumptions — Theories X and Y — in the context of contemporary project–based activity and flexible organizational structures. The research is grounded in
K. V. Kulikov
doaj   +1 more source