Results 151 to 160 of about 16,879 (311)

Photochemical Preparation of (Aza−)Indolines: Diastereoselective Synthesis and Polarity Reversal Strategy

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 13, July 23, 2025.
Abstract Herein, we present the first light‐mediated, diastereoselective de novo synthesis for 2,3‐substituted indolines, a privileged scaffold in pharmaceuticals. The protocol was tested with various aryl and alkyl groups, maintaining high yields up to 85% across different substituents.
Julian J. Melder   +7 more
wiley   +1 more source

Stereocontrol in Conformationally Stable C(sp2)─C(sp3) Atropisomers

open access: yesAngewandte Chemie, Volume 137, Issue 28, July 7, 2025.
Building in our expertize in the synthesis of trans‐dihydrobenzofurans via organocatalyzed domino Michael/O‐cyclization between β‐naphthols and nitroalkenes, we developed an efficient strategy to access a new family of atropisomers bearing a conformationally stable C(sp2)─C(sp3) bond and two stereogenic centers through simple and highly ...
Antoine Domain   +10 more
wiley   +2 more sources

Asymmetric total synthesis of smyrindiol employing an organocatalytic aldol key step

open access: yesBeilstein Journal of Organic Chemistry, 2012
The first organocatalytic asymmetric synthesis of smyrindiol, by using an (S)-proline catalyzed enantioselective intramolecular aldol reaction as the key step, is described. Smyrindiol was synthesized from commercially available 2,4-dihydroxybenzaldehyde
Dieter Enders   +3 more
doaj   +1 more source

Highly Enantioselective 1,4‐Michael Additions of Nucleophiles to Unsaturated Aryl Ketones with Organocatalysis by Bifunctional Cinchona Alkaloids [PDF]

open access: bronze, 2010
Cristina Gómez de la Oliva   +4 more
openalex   +1 more source

One-pot asymmetric cyclocarbohydroxylation sequence for the enantioselective synthesis of functionalised cyclopentanes

open access: yes, 2010
International audienceA new method has been developed for the enantioselective synthesis of highly functionalised cyclopentanes bearing up to three stereogenic centres with very high stereoselectivity.
Bonne, Damien   +4 more
core   +3 more sources

Impact of the Substitution Pattern in N–heterocyclic Olefin‐Substituted Phosphines on Palladium Catalysis

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 13, July 23, 2025.
The impact of olefin backbone substitution in N‐heterocyclic olefin‐substituted phosphines is investigated. While these ligands are highly electron‐donating, their catalytic activity in Pd‐catalyzed CN cross‐coupling reactions decreases as the size of the backbone substituent increases.
Nicolas Kaiser   +3 more
wiley   +1 more source

Synergistic Visible Light Nanophotocatalysis and Asymmetric Organocatalysis for the Stereoselective α‐Alkylation of Aldehydes

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 13, July 23, 2025.
An unprecedent dual catalytic nanophotocatalytic and asymmetric organocatalytic system for the α‐functionalization of aldehydes is developed using carbon nanodots as photosensitizers. The optimized methodology yields the alkylated products with up to 94% yield and up to 98:2 e.r., evidencing the possible recycling of the nanocatalysts.
Antonio Di Sabato   +9 more
wiley   +1 more source

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