Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Aspectos actuales de la organogénesis. Función e involución del timo
El timo es un órgano linfoide central o primario localizado en la parte anterosuperior del tórax. Constituye el principal sitio de diferenciación y maduración de las células T.
Vianed Marsán Suárez +2 more
doaj
Overcoming Recalcitrance: A Review of Regeneration Methods and Challenges in Roses. [PDF]
Nelson A +5 more
europepmc +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
Beyond the Bottleneck: Predicting Regeneration Potential in Sunflower Through Integrated Morphological and Statistical Profiling. [PDF]
Ionas K +6 more
europepmc +1 more source
ABSTRACT Rachipagus parasitic twinning is an exceptionally rare clinical entity resulting from an asymmetric monozygotic twinning process, characterized by a dorsally co‐joined partially formed twin. Co‐ existence of this condition with neural tube defect is uncommon, yet clinically significant.
Biruk Lealem +2 more
wiley +1 more source
Correction: Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale. [PDF]
Imaz-Rosshandler I +12 more
europepmc +1 more source
Evolution of Resistance to Avian Malaria Infection in an Endemic Hawaiian Honeycreeper
Hawaiian honeycreepers, a group of endemic song birds, represent one of the most stunning examples of an adaptive radiation. An evolutionary history devoid of malaria‐causing parasites has made them incredibly susceptible to disease. This work sought to identify genomic correlates of avian malaria infection.
John H. Neddermeyer +5 more
wiley +1 more source
Unveiling Embryonic Development of the Threatened Neotropical Fish <i>Prochilodus vimboides</i> (Characiformes: Prochilodontidae). [PDF]
Honji RM +5 more
europepmc +1 more source
Antenatal Presentation of MRPS22‐Related Mitochondrial Disease Confirmed With Rapid Proteomics
ABSTRACT MRPS22‐related mitochondrial disease (MIM#611719) is a rare autosomal recessive disorder caused by defects in the mitochondrial ribosomal protein S22, a component of the small mitoribosomal subunit essential for mitochondrial translation. Of the few reported cases, most present antenatally with a severe phenotype, conveying a poor prognosis ...
Liana N. Semcesen +43 more
wiley +1 more source

