In Vitro Anti-SARS-CoV-2 Activity of Selected Metal Compounds and Potential Molecular Basis for Their Actions Based on Computational Study [PDF]
Biomolecules, 2021 Metal-based drugs represent a rich source of chemical substances of potential interest for the treatment of COVID-19. To this end, we have developed a small but representative panel of nine metal compounds, including both synthesized and commercially ...
Damiano Cirri +8 more
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Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent—In Vitro and In Vivo Studies [PDF]
PharmaceuticsBackground/Objectives: The therapeutic management of melanoma, the most aggressive form of skin cancer, remains challenging. In the search for more effective therapeutic options, metal-based complexes are being investigated for their anticancer ...
Jacinta O. Pinho +9 more
doaj +2 more sources
Mechanisms of Cytotoxicity of Selected Organogold(III) Compounds [PDF]
Journal of Medicinal Chemistry, 2005 The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications.
Maria Agostina Cinellu +2 more
exaly +6 more sources
Aurophilic interaction-based aggregation of gem-digold(I) aryls towards high spin-orbit coupling and strong phosphorescence [PDF]
Nature CommunicationsLuminescent gold(I) compounds have attracted intensive attention due to anticipated strong spin-orbit coupling (SOC) resulting from heavy atom effect of gold atoms. However, some mononuclear gold(I) compounds are barely satisfactory. Here, we unveil that
Xiao-Yi Zhai, Liang Zhao
doaj +2 more sources
Solution chemistry and cytotoxic properties of novel organogold(III) compounds [PDF]
Bioorganic and Medicinal Chemistry, 2004 The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following compounds were considered: [Au(bipy(dmb)-H)(2,6-xylidine-H)][PF(6)] (AuXyl) and [Au(bipy(dmb)-H)(p-toluidine-H)][PF(6 ...
Maria Agostina Cinellu +2 more
exaly +5 more sources
An Organogold Compound as Potential Antimicrobial Agent against Drug-Resistant Bacteria: Initial Mechanistic Insights. [PDF]
ChemMedChem, 2021 AbstractThe rise of antimicrobial resistance has necessitated novel strategies to efficiently combat pathogenic bacteria. Metal‐based compounds have been proven as a possible alternative to classical organic drugs. Here, we have assessed the antibacterial activity of seven gold complexes of different families. One compound, a cyclometalated Au(III) C^N
Chakraborty P +5 more
europepmc +6 more sources
Frontiers in Microbiology, 2023 IntroductionAntimicrobial resistance is a pressing global concern that has led to the search for new antibacterial agents with novel targets or non-traditional approaches.
Carlos Ratia +14 more
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Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound [PDF]
Chemical Communications, 2022 With the idea of exploiting metal-templated reactions to achieve selective modification of cysteines in proteins for antibacterial applications, an organometallic cyclometalated Au(III) compound was explored in a competitive chemoproteomic approach based on the isoDTB-ABPP (isotopically labelled desthiobiotin azide-activity-based protein profiling ...
Claudia Schmidt +4 more
openaire +3 more sources
The Beauty of Gold: Knowledge of Mechanisms Leads to Different Applications of Organogold Compounds in Medicine and Catalysis [PDF]
Chemistry Letters, 2021 This review is aimed at providing a concise overview of the results obtained by our group in the field of organometallic chemistry of gold. Therefore, a selection of examples amongst the most extensively explored families of bioactive gold complexes — Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds — is presented.
Casini, Angela, Thomas, Sophie R.
openaire +2 more sources
Chirality Induction in Bioorganometallic Conjugates
Inorganics, 2018 Considerable attention has been given to the research field of bioorganometallic chemistry, which is a hybrid chemistry field between biology and organometallic chemistry.
Toshiyuki Moriuchi +2 more
doaj +1 more source