Results 101 to 110 of about 114,312 (393)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics

bioRxiv, 2022
Organoids have immense potential as ex vivo disease models for drug discovery and personalized drug screening. Dynamic changes in individual organoid morphology, number, and size can indicate important drug responses, however these metrics are difficult ...
Jonathan Matthews, Brooke Schuster, S. S. Kashaf, Ping Liu, M. Bilgic, A. Rzhetsky, S. Tay   +6 more
semanticscholar   +1 more source

Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling

Stem Cell Research & Therapy
The lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applications.
Weidong Shao, Hui Xu, Kanghua Zeng, Mingzhou Ye, Renjun Pei, Kai Wang   +5 more
doaj   +1 more source

Developments in endoderm and pancreatic β-cell differentiation from human pluripotent stem cells [PDF]

Organoid
Human pluripotent stem cells (hPSCs) can differentiate into any cell type in the body, including cells or tissues from ectodermal, mesodermal, or endodermal lineages.
Dong Hyeon Lee, Hwajung Choo, Hyo Yi Choi, Sung Hwan Lee   +3 more
doaj   +1 more source

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources

Organoids in virology

npj Viruses
AbstractTo adequately prepare against imminent disease outbreaks from diverse and ever-changing viral pathogens, improved experimental models that can accurately recapitulate host-virus responses and disease pathogenesis in human are essential. Organoid platforms have emerged in recent years as amenable in vitro tools that can bridge the limitations of
Chu, Julie T. S., Lamers, Mart M.
openaire   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Bone-organ axes: bidirectional crosstalk

Military Medical Research
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines).
An-Fu Deng, Fu-Xiao Wang, Si-Cheng Wang, Ying-Ze Zhang, Long Bai, Jia-Can Su   +5 more
doaj   +1 more source

The Application and Challenges of Brain Organoids in Exploring the Mechanism of Arbovirus Infection

Microorganisms
Arboviruses, transmitted by blood-sucking arthropods, are responsible for significant human and animal diseases, including fever, hemorrhagic fever, and encephalitis, posing a serious threat to global public health.
Baoqiu Cui, Zhijie Wang, Anum Farid, Zeyu Wang, Kaiyue Wei, Naixia Ren, Fengtang Yang, Hong Liu   +7 more
doaj   +1 more source

Advancements in brain organoid models for neurodegenerative disease research [PDF]

Organoid
Neurodegenerative diseases (NDs) such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are progressive disorders characterized by complex, human-specific pathology that poses challenges to drug discovery efforts. Traditional models, including two-
Soomin Park, Jong-Chan Park
doaj   +1 more source