Results 131 to 140 of about 90,274 (350)
Organoids: Avatars for Personalized Medicine
The Keio Journal of Medicine, 2019 Stem cells are the foundation of all mammalian life. Stem cells build and maintain our bodies throughout life. Two types of stem cells are discerned.1) Embryonic stem cells (ES cells) are briefly present in the early human or mouse embryo, a few days after fertilization.
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao +20 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans +11 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel +6 more
wiley +1 more source
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]
, 2020 BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark +20 more
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Organoids in image-based phenotypic chemical screens [PDF]
, 2021 Ilya Lukonin +2 more
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Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Pathological progression induced by the frontotemporal dementia-associated R406W tau mutation in patient-derived iPSCs [PDF]
, 2019 Mutations in the microtubule-associated protein tau (MAPT) gene are known to cause familial frontotemporal dementia (FTD). The R406W tau mutation is a unique missense mutation whose patients have been reported to exhibit Alzheimer\u27s disease (AD)-like ...
et al,, Karch, Celeste M, Nakamura, Mari
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A Prospective Feasibility Trial to Challenge Patient–Derived Pancreatic Cancer Organoids in Predicting Treatment Response [PDF]
, 2021 Alica K. Beutel +15 more
openalex +1 more source