Results 221 to 230 of about 90,274 (350)

Artificial Intelligence in Organoid-Based Disease Modeling: A New Frontier in Precision Medicine. [PDF]

Biomimetics (Basel)
Balkhair O, Albalushi H.
europepmc   +1 more source

Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine [PDF]

Shanqiang Qu, Rongyang Xu, Guozhong Yi, Zhiyong Li, Huayang Zhang, Songtao Qi, Guanglong Huang   +6 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Modeling human placental biology: a review of organoid technologies. [PDF]

Front Cell Dev Biol
Bashi A, Joseph T, Schuch V, Johnson EL.
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Development and characterization of chicken lung organoids for in vitro modeling of avian influenza virus-host cell interaction. [PDF]

Sci Rep
Nicholson HF, Zdyrski C, Leyson CM, Corbett MP, Kumar N, Catucci M, Melvin BJ, Stabler LJ, Lakdawala SS, Douglass E, Lowen AC, Mochel JP, Allenspach K, Carnaccini S.   +13 more
europepmc   +1 more source

Thyroid organoids: Advances and applications

, 2023
Jinlu Zhao, Yi Ren, Zhenzhong Ge, Xingyu Zhao, Wang Li, He Wang, Meng Jiang   +6 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Construction of biomimetic gradient-structured cartilage organoids and mechanistic study of their application for cartilage rejuvenation. [PDF]

Bioact Mater
Miao X, Kong K, Rong K, Song Q, Guo T, Zhang C, Wu Q, Zhai Z, Sun Y, Gan Y, Xiang M, Dai K, Atala A, Lu Z.   +13 more
europepmc   +1 more source

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids [PDF]

, 2019
Y. Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F. Chen‐Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai   +16 more
openalex   +1 more source