Results 221 to 230 of about 58,747 (290)

Establishment of Breast Cancer Organoids: A Systematic Review and Meta-Analysis. [PDF]

Int J Breast Cancer
Rocha VM, Katayama MLH, Amorim LO, de Oliveira BD, Lopez RVM, Folgueira MAAK.   +5 more
europepmc   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications. [PDF]

MedComm (2020)
Li K, Cao R, Li M, Tian Z, Fan H, Hong B, Liu X.   +6 more
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Translational 3D <i>in vitro</i> models for immunotherapy testing: from reconstituted organoid co-culture assays to autologous <i>ex vivo</i> patient tissues. [PDF]

Front Immunol
de Man S, Kaya-Aksoy E, Veenendaal T, Meesters N, Chavez Abiega S, Yan X, Kop M, Gandini L, Flach J, Meng J, Zhang M, Teodosieva V, Hanrath J, Foini C, Stessuk T, Spanjaard E, Shih R, Tu X, Zhou J, Wang P, Beztsinna N, Goverse G, Bourré L, Basten S, Putker M.   +24 more
europepmc   +1 more source

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source

Organoid models: reshaping the paradigm for precision development and evaluation of CAR-T cell therapies. [PDF]

Front Bioeng Biotechnol
Li H, Yan J, Liu Y, Tao X, Guo K, Zhang J.   +5 more
europepmc   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Application of spatial transcriptomics across organoids for a high-resolution, spatial whole-transcriptome benchmarking dataset. [PDF]

iScience
Nucera MR, Charitakis N, Leung RF, Leichter A, Tuano NK, Walkiewicz M, Sawant V, Rowley L, Scurr M, Er PX, Tan KS, Sutton R, Ahmad F, Saxena R, Maytum A, Turner DL, Voges HK, Nim HT, Sun KX, Yang B, Li NL, Ball G, Elefanty AG, Lamandé SR, Lawlor KT, Vanslambrouck JM, Mills RJ, Ng ES, Stanley EG, Werder RB, Little MH, Elliott DA, Porrello ER, Faux MC, Eisenstat DD, Velasco S, Rossello FJ, Ramialison M.   +37 more
europepmc   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source