Results 311 to 320 of about 114,312 (393)

Robotic micromanipulation for patterned and complex organoid biofabrication. [PDF]

Sci Adv
Tong M, Huang G, Zhuang S, Yu X, Hu D, Lin W, Wu Y, Chen Y, Cheng S, Jiang M, Zhang L, Gao H.   +11 more
europepmc   +1 more source

hPSC-derived lung and intestinal organoids as models of human fetal tissue

, 2016
Megan Aurora, Jason R. Spence
openalex   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration. [PDF]

Nat Commun
Li XJ, Morgan C, Li L, Zhang WY, Chrysostomou E, Doetzlhofer A.   +5 more
europepmc   +1 more source

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science, EarlyView.
Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
wiley   +1 more source

3D bioprinting bone/cartilage organoids: construction, applications, and challenges. [PDF]

J Orthop Translat
Gao D, Li R, Pan J, Li C, Zhang W, Qin L, Lai Y.   +6 more
europepmc   +1 more source

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

, 2016
Yoshimasa Saito, Toshiaki Nakaoka, Kasumi Sakai, Toshihide Muramatsu, Kohta Toshimitsu, Masaki Kimura, Takanori Kanai∥, Toshiro Sato, Hidetsugu Saito   +8 more
openalex   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Organoids in biliary research: insights into developmental signaling and applications in disease modeling. [PDF]

Front Cell Dev Biol
Peng B, Huang M, Zhang J, Xiang Y.
europepmc   +1 more source

Construction of Thymus Organoids from Decellularized Thymus Scaffolds

, 2016
Asako Tajima, Isha Pradhan, Xuehui Geng, Massimo Trucco, Yong Fan   +4 more
openalex   +2 more sources