Results 341 to 350 of about 114,312 (393)

CDK4/6 Inhibitor Priming Enhances PD‐1 Blockade via Sellhi Neutrophil‐Induced Stat5a+ Progenitor Exhausted CD8+ T Cell

Advanced Science, EarlyView.
Activated tumor‐intrinsic cyclin D1‐CDK4/6 signaling attenuates lymphocyte infiltration, and consequently, and immunotherapy resistance in HNSCC. It is discovered that brief CDK4/6i priming before anti‐PD‐1 results in enhanced durability of ICB response durability through Stat5a+ progenitor exhausted CD8+ T cells induced by IL15‐secreted Sell(hi ...
Yu Zhang, Bao Sun, Rong Zhou, Zizhen Gong, Yong Han, Wenjie Tao, Chaoji Shi, Wuchang Zhang, Laikui Liu, Zhiyuan Zhang, Jiang Li, Qi Zhu, Weiwen Zhu, Ziyue Gu   +13 more
wiley   +1 more source

Protocol for generation and utilization of patient-derived organoids from multimodal specimen. [PDF]

STAR Protoc
Kang S, Lee MR, Choi W, Kong SY, Kim YH.
europepmc   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer. [PDF]

Stem Cells Transl Med
Bell M, Krasnodembskaya AD.
europepmc   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

IDP-Head: An Interactive Dual-Perception Architecture for Organoid Detection in Mouse Microscopic Images. [PDF]

Biomimetics (Basel)
Yang Y, Fan C, Zhou X, Wei P.
europepmc   +1 more source

Human cerebral organoids model tumor initiation and infiltration in an autologous astrocyte-supported setting. [PDF]

iScience
Schickel E, Bender T, Kaysan L, Hufgard S, Mayer M, Grosshans DR, Thielemann C, Schroeder IS.   +7 more
europepmc   +1 more source

Correction: Application and development of Organ-on-a-Chip technology in cancer therapy. [PDF]

Front Oncol
Wang LX, Liu SL, Wu N.
europepmc   +1 more source

Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy. [PDF]

Proc Natl Acad Sci U S A
Wan Z, Li C, Zhou Y, Yu Y, Chiu MC, Huang J, Zhang S, Zhu X, Lan Q, Deng Y, Xue W, Jiang C, Wu J, Zhao Z, Cai JP, Huang L, Zhang Y, Liu X, Zhang Z, Chu H, Zhang L, Chen Z, To KK, Yuen KY, Clevers H, Zhou J.   +25 more
europepmc   +1 more source

Multi-layer stratified oncology platform utilizing transcriptomics, prostate cancer organoids, and modeling of drug response. [PDF]

J Exp Clin Cancer Res
Kang J, Chouvardas P, Maalouf A, Hanhart D, Cerro LF, Cheng W, Compérat E, Ovchinnikova K, Etter R, Medová M, Schneeberger U, Roth B, Thalmann GN, Karkampouna S, Kruithof-de Julio M.   +14 more
europepmc   +1 more source