Results 91 to 100 of about 1,044,908 (274)

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. [PDF]

, 2019
Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ (DCIS) are poorly understood.
Alečković, Maša, Allred, D Craig, Argani, Pedram, Au, Alfred, Babski, Kirsten, Bissell, Mina, Bloushtain-Qimron, Noga, Blum, Joanne L, Bobolis, Kristie, Bonal, Dennis M, Caulfield, Ryan J, Choudhury, Sibgat, Cristea, Simona, Dillon, Deborah, Ding, Lina, Ekram, Muhammad, Ethington, Gabrielle, Fan, Rong, Fassl, Anne, Garber, Judy E, Gil Del Alcazar, Carlos, Grant, Michael, Harper, Nicholas W, Herlihy, William, Hines, William C, Hinohara, Kunihiko, Huh, Sung Jin, Hwang, E Shelley, Jovanović, Bojana, Kim, Elizabeth Min Hui, Kleer, Celina G, Long, Henry W, McDonnell, Charles H, Merino, Vanessa F, Nguyen, Quang-De, Panos, Laura, Park, So Yeon, Polyak, Kornelia, Qiu, Xintao, Richardson, Andrea L, Rosson, Gedge D, Rowberry, Ron, Sicinski, Piotr, Su, Ying, Sukumar, Saraswati, Wagner, Jon, Yao, Jun, Zi, Xiaoyuan   +47 more
core   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Organoid‐based novel technology for antitumor drug screening

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Organoids are an emerging biomedical research model that can highly mimic the key physiological characteristics and biological functions of organs in vivo, achieving significant breakthroughs in tumor immunotherapy drug screening.
Yu Su, Yuan Chen, Guanning Wei, Yihai Shi   +3 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

3D Neuron Cluster Organoid – Artificial Intelligence using High-Speed Organic Neural Network

Applied Medical Informatics, 2023
Since the beginning of time, Humanity has relied on the careful analysis of nature to better understand the world around us. The same can be said of our current Bio-Technical Research Environment and our feeble Artificial Intelligence endeavors.
Cristian-Horia CONSTANTIN, Marieta FURDUI   +1 more
doaj  

A Survey of AI Utilisation in High-Throughput Screening Systems Using Stem Cell Models [PDF]

Human pluripotent stem cells (hPSCs) have been increasingly used for disease modelling and drug screening. Recently, hPSCs also give rise to develop functional 3D human organoids which prove to possess closer function and physiology in vitro.
Cao, Lu, Schwach, Verena, Verbeek, Fons
core   +1 more source

Regen med therapeutic opportunities for fighting COVID-19. [PDF]

, 2021
This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID-19.
Ahsan, Taby, Albanna, Mohammad, Atala, Anthony, Cetrulo, Kyle, Eaker, Shannon, Greenberg, Jordan, Henn, Alicia, Hunsberger, Joshua, Krukin, Jeff, Lundberg, Martha, Lutz, Cathleen, Lynum, Steven, Pereira, Taciana   +12 more
core   +1 more source

Innovative Metasurface Colorimetric Cell‐on‐a‐Chip Sensor for Continuous, Label‐Free, Non‐Destructive Assessment of Intestinal Barrier Dynamics

Advanced Science, EarlyView.
We developed a real‐time, label‐free, high‐throughput cell‐on‐a‐chip system based on a metasurface plasmon resonance colorimetric sensor (MetaSPRCS) to evaluate intestinal barrier function. This platform enables continuous monitoring of cell adhesion, proliferation, and barrier layer formation, disruption, and repair.
Youqian Chen, Wen Li, Jiaying Feng, Yue Shu, Yihui Yang, Yuyan Wang, Rui Li, Hanlin Zhou, Xinfan Yang, Yuxue Guo, Mingqian Chen, Wenjun Hu, Gang Logan Liu, Liping Huang, Yanan Li   +14 more
wiley   +1 more source

Roadmap on Artificial Intelligence‐Augmented Additive Manufacturing

Advanced Intelligent Systems, EarlyView.
This Roadmap outlines the transformative role of artificial intelligence‐augmented additive manufacturing, highlighting advances in design, monitoring, and product development. By integrating tools such as generative design, computer vision, digital twins, and closed‐loop control, it presents pathways toward smart, scalable, and autonomous additive ...
Ali Zolfagharian, Liuchao Jin, Qi Ge, Wei‐Hsin Liao, Andrés Díaz Lantada, Francisco Franco Martínez, Tianyu Zhang, Tao Liu, Charlie C. L. Wang, Mohammad Hossein Mosallanejad, Reza Ghanavati, Abdollah Saboori, Alejandro De Blas De Miguel, William Solórzano‐Requejo, Yi Cai, Xiangyang Dong, Huangyi Qu, Najmeh Samadiani, Guangyan Huang, Austin Downey, Yanzhou Fu, Lang Yuan, Tsz‐Kwan (Glory) Lee, Arbind Agrahari Baniya, Eisha Waseem, Abdul Rahman Sani, Abbas Z. Kouzani, Yijia Wu, Markus P. Nemitz, Masoud Shirzad, Dageon Oh, Seung Yun Nam, Amedeo Franco Bonatti, Irene Chiesa, Gabriele Maria Fortunato, Giovanni Vozzi, Carmelo De Maria, Mahdi Bodaghi   +37 more
wiley   +1 more source