Results 121 to 130 of about 2,401,578 (298)
National Intelligence Daily (Cable) 24 March 1982 [PDF]
, 1982 Declassified on 2017-11 ...
United States. Central Intelligence Agency. +1 more
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Harnessing bacterial extracellular vesicles for bone and cartilage organoids
BMEMat, EarlyView.This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu +8 more
wiley +1 more source
BMEMat, EarlyView.To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv +3 more
wiley +1 more source
From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs
Clinical Pharmacology &Therapeutics, EarlyView.New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley +1 more source
An Ethical Analysis of Human Cerebral Organoids
Yixue yu zhexueHuman cerebral organoids are three-dimensional neural tissues with similar structure and biological function to human brain. Human cerebral organoids can be used to study human brain development, disease mechanisms, and drug screening.
Bin HUANG
doaj +1 more source
National Intelligence Daily 28 July 1983 [PDF]
, 1983 Declassified on 2017-11 ...
United States. Central Intelligence Agency.
core
Clinical Pharmacology &Therapeutics, EarlyView.Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart +16 more
wiley +1 more source
bioRxivCRISPR-Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9) provides powerful gene-editing tools that are applicable for gene therapy of a variety of diseases including, but not limited to cancer, rare diseases ...
WR Danter
semanticscholar +1 more source
Organoid-ICLIP: Class imbalance-aware vision-language learning for organoid mitosis classification
Visual analysis of brain organoid imaging is critical for advancing the understanding of in vitro organoid development. However, precise differentiation of mitotic stages remains challenging due to complex cellular morphology and limited imaging data. To
Anabia Sohail (22171822) +2 more
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National Intelligence Daily (Cable) 21 August 1982 [PDF]
, 1982 Declassified on 2017-11 ...
United States. Central Intelligence Agency.
core