Results 141 to 150 of about 2,401,578 (298)
National Intelligence Daily 15 December 1983 [PDF]
, 1983 Declassified on 2017-11 ...
United States. Central Intelligence Agency.
core
Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond
Exploration, EarlyView.Traditional drug development is time‐consuming and costly, and new tools are urgently needed to improve efficiency. This perspective reviews the considerable potential of AlphaFold 3 as a next‐generation predictive tool for drug discovery, particularly in target identification and validation, hit identification and lead optimization, and personalized ...
Songlin He +6 more
wiley +1 more source
Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine
PharmaceuticalsBackground/Objectives: Human pluripotent stem cells (hPSCs) and organoid technologies are transforming pharmaceutical research by providing models that more accurately reflect human physiology, genetic variability, and disease mechanisms.
Eleanor Luce, Jean-Charles Duclos-Vallee
doaj +1 more source
National Intelligence Daily (Cable) 10 March 1982 [PDF]
, 1982 Declassified on 2017-11 ...
United States. Central Intelligence Agency.
core
Gut Medicine, EarlyView.ABSTRACT Reproducing tumor biology in vivo using three‐dimensional organoids remains a debated topic in the cancer organoid field, despite the new FDA framework for evaluating cancer drugs with organoid models. Compared with patient‐derived organoids (PDOs), which offer a humanized model for testing cancer therapies, organoids derived from normal stem ...
Chong Gao
wiley +1 more source
Immune Organoids: A Review of Their Applications in Cancer and Autoimmune Disease Immunotherapy
Current Issues in Molecular BiologyImmune organoids have emerged as a ground-breaking platform in immunology, offering a physiologically relevant and controllable environment to model human immune responses and evaluate immunotherapeutic strategies.
David B. Olawade +4 more
doaj +1 more source
, 1993 Map of the newly independent states showing final assembly plants, production facilities, international boundaries, water features and major cities.; "727015 (R00781) 1-93."; On accompanying title sheet and booklet: OSE 93-10001, January 1993.; At head ...
United States. Central Intelligence Agency. Directorate of Intelligence.
core
International Journal of Cancer, EarlyView.Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia +4 more
wiley +1 more source
World Journal of Surgical OncologyThe organoid approach preserves the intricate molecular and genetic characteristics of tumor tissues, playing a pivotal role in advancing precision oncology.
Xiaoting Wang, Danyan Lin, Ninghan Feng
doaj +1 more source
iMetaMed, EarlyView.This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu +7 more
wiley +1 more source