Results 41 to 50 of about 1,044,908 (274)

Human Brain Organoids in Migraine Research:Pathogenesis and Drug Development [PDF]

, 2023
Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that have started to revolutionize medical science in terms of understanding disease, testing pharmacologically active compounds, and offering novel ways to treat disease ...
Gazerani, Parisa
core   +3 more sources

Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

npj Precision Oncology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases, characterized by a treatment-resistant and invasive nature. In line with these inherent aggressive characteristics, only a subset of patients shows a clinical response to the ...
Maxim Le Compte, Edgar Cardenas De La Hoz, Sofía Peeters, Felicia Rodrigues Fortes, Christophe Hermans, Andreas Domen, Evelien Smits, Filip Lardon, Timon Vandamme, Abraham Lin, Steve Vanlanduit, Geert Roeyen, Steven Van Laere, Hans Prenen, Marc Peeters, Christophe Deben   +15 more
doaj   +1 more source

A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids

Cancer Biology & Medicine, 2023
Objective: Organoids are a powerful tool with broad application prospects in biomedicine. Notably, they provide alternatives to animal models for testing potential drugs before clinical trials. However, the number of passages for which organoids maintain
Ruixin Yang, Yutong Du, Wingyan Kwan, Ranlin Yan, Qimeng Shi, Lu Zang, Zhenggang Zhu, Jianming Zhang, Chen Li, Yingyan Yu   +9 more
doaj   +1 more source

Organoid intelligence: training lab-grown mini-brains to learn and compute with AI

AAPS Open
L. R. Jaidev Chakka, Mohammed Maniruzzaman   +1 more
doaj   +2 more sources

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling [PDF]

, 2019
With 100 billion neurons and 100 trillion synapses, the human brain is not just the most complex organ in the human body, but has also been described as “the most complex thing in the universe.” The limited availability of human living brain tissue for ...
Allende, Almeida, Amenduni, Ananiev, Auger, Avior, Awad, Baarine, Barral, Basuodan, Bershteyn, Bhinge, Biedler, Biedler, Bilican, Bird, Birey, Bousquet, Boza-Moran, Brammer, Brawner, Brewer, Bridget E. Bax, Brodal, Camp, Carlessi, Carpenter, Carter, Chamberlain, Chambers, Chandrasekaran, Chang, Chesselet, Clevers, Cohen, Conti, Corti, Costero, Coyle, Crain, Cugola, Cunningham, Curchoe, Dang, Dario Pacitti, Dawson, DeFelipe, Denham, Denton, Dezonne, Di Lullo, Dickinson, Diez del Corral, Dingle, Djuric, Doerr, Doers, Dotti, Ebert, Edri, Efthymiou, Egawa, Eigentler, Eiraku, Eiraku, Elston, Eyal, Fernandez-Santiago, Fietz, Filis, Foo, Franco, Frotscher, Fuller, Garcez, Gaspard, Ge, Gharib, Giandomenico, Giulian, Goldman, Goldstein, Golgi, Gomes, Gonzalez-Cordero, Gordon, Gotz, Greene, Griesi-Oliveira, Gähwiler, Halevy, Hall, Hansen, Harrison, Harrison, Hartung, Haubensak, Havlicek, Herculano-Houzel, Hick, Higuchi, Higurashi, Hoadley, Hogue, Hogue, Howard, Huang, Hughes, Iefremova, Imura, Itskovitz-Eldor, Jaenisch, Jakel, Janesick, Jang, Jiang, Jiao, Jo, Johns, Kadoshima, Kelava, Kelava, Kim, Kirkeby, Kleinman, Knopfel, Ko, Komssi, Kovalevich, Kuff, Lancaster, Lancaster, Lancaster, Lancaster, Lange, LaVail, Lavazza, Lee, Lee, Lee, Lee, Lee, LePage, Li, Liddelow, Lingor, Liu, Liu, Liu, Liu, Lohle, Lojewski, Ma, Maden, Mansour, Marchetto, Mariani, Mariani, Mastrangelo, Matsui, Mattei, McCarthy, McGivern, McKinney, Mellios, Miranda, Miranda, Miranda, Mishra, Miyata, Mohan, Monzel, Muguruma, Muotri, Nayler, Ng, Nguyen, Nizzardo, Nzou, Okita, Ostergaard, Pacitti, Pacitti, Pahlman, Panicker, Park, Park, Pasca, Pasca, Pasca, Patitucci, Pauklin, Paşca, Pekny, Petros, Pham, Pleasure, Puschmann, Puschmann, Qian, Quadrato, Raja, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Renner, Reubinoff, Reynolds, Riccardo Privolizzi, Ricciardi, Ring, Robertson, Roth, Rowitch, Sakaguchi, Sanchez-Danes, Sareen, Schuldiner, Schwab, Schwartz, Schwartz, Serio, Shcheglovitov, Shepherd, Shi, Shi, Shipley, Siegenthaler, Sloan, Sneddon, Soldner, Stan, Stubbs, Suga, Sun, Sun, Sun, Sutcliffe, Tachibana, Takahashi, Tang, Temple, Thomson, Tian, Tibbitt, Tiscornia, Tonge, Trilck, Ullrich, Ungrin, Urbach, Uusi-Rauva, Velasco, Vescovi, Vessoni, Vierbuchen, Villanueva, Waddington, Waddington, Walsh, Wang, Watanabe, Wataya, Whetsell, Williams, Wilson, Wood, Workman, Wu, Xu, Yakoub, Yakoub, Yamashita, Yang, Yang, Ye, Yin, Ying, Yoshida, Zhang, Zhang, Zhang, Zhu, Zhu, Zhu   +285 more
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Ethical issues related to brain organoid research [PDF]

, 2020
This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery ...
Hyun, Insoo, Lunshof, Jeantine E., Scharf-Deering, J. C.   +2 more
core   +1 more source

Brain organoids - model systems of the human brain: Statement [PDF]

, 2023
Brain organoids are tissue structures created in the lab, which imitate certain functions of the brain. As a simplified model system, they enable experimental access to questions surrounding the development and function of the human brain.
Deutsche Akademie der Naturforscher Leopoldina
core   +1 more source

Artificial intelligence-enabled studies on organoid and organoid extracellular vesicles

Biomaterials translational
Han Liu, James T. Triffitt, Zhidao Xia, Jiacan Su   +3 more
semanticscholar   +3 more sources

Data-driven modelling of the FRC network for studying the fluid flow in the conduit system [PDF]

, 2016
The human immune system is characterized by enormous cellular and anatomical complexity. Lymph nodes are key centers of immune reactivity, organized into distinct structural and functional modules including the T-cell zone, fibroblastic reticular cell ...
Igor Sazonov, Raoul van Loon
core   +1 more source

A systematic approach to cancer: evolution beyond selection. [PDF]

, 2017
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core   +1 more source