Results 11 to 20 of about 1,169 (124)
Organoides de cérebro como modelos de doenças de Alzheimer e Parkinson: uma revisão narrativa sobre as perspectivas para medicina regenerativa e personalizada [PDF]
Medicina, 2023 Há muitos anos a cultura celular bidimensional (2D) é utilizada como modelo de estudo de doenças, possuindo grande importância na medicina regenerativa, apesar de ainda conter limitações significativas.
Raysa Taynara Vasconcelos de Souza +6 more
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Afrontar los desafíos éticos del consentimiento informado para la donación de tejido cerebral [PDF]
Medicina y ÉticaLa enorme promesa médica de los organoides humanos ha llevado a grandes instituciones de investigación y organismos nacionales a crear bancos de tejido cerebral.
Amitabha Palmer
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Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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INRAE Productions Animales, 2023 L’intestin est un organe complexe aux fonctions multiples. En effet, il participe à la digestion et l'absorption des nutriments et protège l’individu des agressions par des agents pathogènes intestinaux en assurant un rôle de barrière.
Agnès WIEDEMANN +1 more
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Isolation, Culture and Characterization of Klinefelter Spermatogonial Stem Cells [PDF]
, 2023 [eng] INTRODUCTION: Klinefelter syndrome (KS) is a chromosomal abnormality that affects approximately 1 in 500-1000 male births. Their most frequent karyotype is 47XXY and up to 10% of them present significant mosaicism in the study of peripheral blood.
Galdón López, Guillermo
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Bioengineering, 2023 Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature
Hannah A. Strobel +2 more
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New methodologies for old problems: tridimensional gastrointestinal organoids and guts-on-a-chip
Journal of Coloproctology, 2018 Objectives: The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research. Methods: A literature review was performed
Marna Eliana Sakalem +1 more
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