Results 11 to 20 of about 1,177 (126)

Organoides de cérebro como modelos de doenças de Alzheimer e Parkinson: uma revisão narrativa sobre as perspectivas para medicina regenerativa e personalizada [PDF]

Medicina, 2023
Há muitos anos a cultura celular bidimensional (2D) é utilizada como modelo de estudo de doenças, possuindo grande importância na medicina regenerativa, apesar de ainda conter limitações significativas.
Raysa Taynara Vasconcelos de Souza, Pedro Henrique Gomes Santana, Ricardo Cambraia Parreira, Lucas Felipe Oliveira, Adrieli Oliveira Raminelli, Bruno Lemes Marques, Daniel Mendes Filho   +6 more
doaj   +5 more sources

Afrontar los desafíos éticos del consentimiento informado para la donación de tejido cerebral [PDF]

Medicina y Ética
La enorme promesa médica de los organoides humanos ha llevado a grandes instituciones de investigación y organismos nacionales a crear bancos de tejido cerebral.
Amitabha Palmer
doaj   +3 more sources

Organoids

Nature Reviews Methods Primers, 2022
Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao, Xinyi Chen, Anna M. Dowbaj, Aleksandra Sljukic, Kaitlin Bratlie, Luda Lin, Eliza Li Shan Fong, Gowri Manohari Balachander, Zhaowei Chen, Alice Soragni, Meritxell Huch, Yi Arial Zeng, Qun Wang, Hanry Yu   +13 more
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Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy. [PDF]

Br J Surg, 2019
Organoid technology was used to create a preclinical model for evaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases from colorectal cancer. Current HIPEC regimens were tested and a novel rational treatment combination of mitomycin C with inhibitors of ATR was investigated.
Ubink I, Bolhaqueiro ACF, Elias SG, Raats DAE, Constantinides A, Peters NA, Wassenaar ECE, de Hingh IHJT, Rovers KP, van Grevenstein WMU, Laclé MM, Kops GJPL, Borel Rinkes IHM, Kranenburg O.   +13 more
europepmc   +2 more sources

Engineering organoids [PDF]

Nature Reviews Materials, 2021
Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
openaire   +2 more sources

Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]

, 2021
ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz   +6 more
openaire   +1 more source

[Lung organoids].

Medecine sciences : M/S, 2020
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé, Vernisse, Charlotte, Mianné, Joffrey, Fieldes, Mathieu, Ahmed, Engi, Petit, Aurélie, Vachier, Isabelle, Bertrand, Thierry Lavabre, Assou, Said, Bourdin, Arnaud, de Vos, John   +10 more
openaire   +3 more sources

Die Linienmuster der Haut und ihre Dermatosen

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 4, Page 341-365, April 2020., 2020
Zusammenfassung Die Kenntnis der Linienmuster der Haut stellt eine Schlüsselkompetenz für jeden Dermatologen dar. Vier Hauptgruppen von Linienmustern sind relevant: Langer‐Linien, Dermatome, Blaschko‐Linien und exogene Muster. Die Langer‐Linien markieren die Richtung der geringsten Spannung der Haut und sind diagnostisch wichtig für einige ...
Sonja Senner, Laurie Eicher, Suzan Nasifoglu, Andreas Wollenberg   +3 more
wiley   +1 more source

Isolation, Culture and Characterization of Klinefelter Spermatogonial Stem Cells [PDF]

, 2023
Programa de Doctorat en Medicina i Recerca Translacional[eng] INTRODUCTION: Klinefelter syndrome (KS) is a chromosomal abnormality that affects approximately 1 in 500-1000 male births. Their most frequent karyotype is 47XXY and up to 10% of them present
Galdón López, Guillermo
core   +2 more sources

Vascularized Tissue Organoids

Bioengineering, 2023
Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature
Hannah A. Strobel, Sarah M. Moss, James B. Hoying   +2 more
openaire   +3 more sources