Results 21 to 30 of about 479 (131)
New methodologies for old problems: tridimensional gastrointestinal organoids and guts-on-a-chip
Journal of Coloproctology, 2018 Objectives: The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research. Methods: A literature review was performed
Marna Eliana Sakalem +1 more
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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Science, 2019 Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for ...
Sunghee Estelle Park +2 more
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACT Over the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Establecimiento de organoides derivados de pacientes con carcinoma colorrectal como modelo para cribado de drogas con acción antitumoral [PDF]
, 2022 El cáncer colorrectal (CCR) es la segunda causa de muerte por cáncer a nivel mundial, y es el tercero en incidencia. En los últimos años se han realizado grandes avances para entender mejor los aspectos clínico-patológicos y moleculares del CCR lo que ha
Gutiérrez Bravo, María Fernanda
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Los organoides: órganos humanos en miniatura para estudiar enfermedades [PDF]
, 2022 Artículo de divulgación publicado en The Conversation España el día 06/04/2022.Para entender cómo funciona el cuerpo humano y cómo se producen las enfermedades y cómo tratarlas hacemos experimentos.
Martinez, Isidoro +2 more
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Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank [PDF]
Frontiers in Oncology, 2021 Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that stably retain key characteristics of the respective organs. Organoids can be generated from healthy or pathological tissues derived from patients. Cancer organoid culture platforms have several advantages, including conservation of the cellular composition ...
Zilong Zhou, Lele Cong, Xianling Cong
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Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
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Diseño de un método de cultivo de organoides de miocardio derivados de células madre adultas
, 2022 Los organoides son cultivos 3D desarrollados a partir de células madre creando un ambiente artificial propicio, en el cual las células pueden crecer e interactuar en un entorno tridimensional similar a las condiciones de un estado in vivo, imitando su ...
Quesada Quintero, Fabio Andrés +1 more
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Organoides intestinales murinos: diferentes aproximaciones metodológicas
, 2021 Los organoides intestinales constituyen modelos tridimensionales de complejidad intermedia entre los cultivos de líneas celulares y los modelos in vivo, permitiendo aproximaciones de estudio fisiológicamente más relevantes y mejorando el poder ...
Pagotto, Romina +2 more
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