Results 21 to 30 of about 1,268 (144)
Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
openaire +3 more sources
Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
openaire +2 more sources
Die Linienmuster der Haut und ihre Dermatosen
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 4, Page 341-365, April 2020., 2020 Zusammenfassung Die Kenntnis der Linienmuster der Haut stellt eine Schlüsselkompetenz für jeden Dermatologen dar. Vier Hauptgruppen von Linienmustern sind relevant: Langer‐Linien, Dermatome, Blaschko‐Linien und exogene Muster. Die Langer‐Linien markieren die Richtung der geringsten Spannung der Haut und sind diagnostisch wichtig für einige ...
Sonja Senner +3 more
wiley +1 more source
Organoids are not organs: Sources of variation and misinformation in organoid biology
Stem Cell Reports, 2023 In the past decade, the term organoid has moved from obscurity to common use to describe a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of the in vivo organ it models. The term organoid is now applied to structures formed as a result of two distinct processes: the capacity for adult epithelial stem cells ...
Kim Bak Jensen, Melissa Helen Little
openaire +5 more sources
New methodologies for old problems: tridimensional gastrointestinal organoids and guts-on-a-chip
Journal of Coloproctology, 2018 Objectives: The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research. Methods: A literature review was performed
Marna Eliana Sakalem +1 more
doaj +1 more source
Análisis de proliferación y diferenciación celular en organoides de colon murino expuestas al medio condicionado L-WRN y evaluación de la expresión del receptor de tiamina (THR1) [PDF]
, 2022 En los últimos años, los organoides han sido considerados como una de las innovaciones revolucionarias del mundo científico, ya que se trata de un gran avance en la investigación biológica y biomédica moderna.
Sarmiento Sanchez, Lenny Orana
core +2 more sources
Organoides intestinales murinos: diferentes aproximaciones metodológicas
, 2021 Los organoides intestinales constituyen modelos tridimensionales de complejidad intermedia entre los cultivos de líneas celulares y los modelos in vivo, permitiendo aproximaciones de estudio fisiológicamente más relevantes y mejorando el poder ...
Pagotto, Romina +2 more
core +1 more source
Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
openaire +3 more sources
BJS (British Journal of Surgery), Volume 106, Issue 10, Page 1404-1414, September 2019., 2019 Organoid technology was used to create a preclinical model for evaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases from colorectal cancer. Current HIPEC regimens were tested and a novel rational treatment combination of mitomycin C with inhibitors of ATR was investigated.
I. Ubink +13 more
wiley +1 more source