Results 21 to 30 of about 101 (86)

[Lung organoids].

Medecine sciences : M/S, 2020
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé, Vernisse, Charlotte, Mianné, Joffrey, Fieldes, Mathieu, Ahmed, Engi, Petit, Aurélie, Vachier, Isabelle, Bertrand, Thierry Lavabre, Assou, Said, Bourdin, Arnaud, de Vos, John   +10 more
openaire   +3 more sources

Organoides de cérebro como modelos de doenças de Alzheimer e Parkinson: uma revisão narrativa sobre as perspectivas para medicina regenerativa e personalizada

Medicina, 2023
Há muitos anos a cultura celular bidimensional (2D) é utilizada como modelo de estudo de doenças, possuindo grande importância na medicina regenerativa, apesar de ainda conter limitações significativas.
Raysa Taynara Vasconcelos de Souza, Pedro Henrique Gomes Santana, Ricardo Cambraia Parreira, Lucas Felipe Oliveira, Adrieli Oliveira Raminelli, Bruno Lemes Marques, Daniel Mendes Filho   +6 more
doaj  

Organoids-on-a-chip

Science, 2019
Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for ...
Sunghee Estelle Park, Andrei Georgescu, Dongeun Huh   +2 more
openaire   +3 more sources

Organoids by design

Science, 2019
Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
openaire   +3 more sources

Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank [PDF]

Frontiers in Oncology, 2021
Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that stably retain key characteristics of the respective organs. Organoids can be generated from healthy or pathological tissues derived from patients. Cancer organoid culture platforms have several advantages, including conservation of the cellular composition ...
Zilong Zhou, Lele Cong, Xianling Cong
openaire   +3 more sources

Afrontar los desafíos éticos del consentimiento informado para la donación de tejido cerebral

Medicina y Ética
La enorme promesa médica de los organoides humanos ha llevado a grandes instituciones de investigación y organismos nacionales a crear bancos de tejido cerebral.
Amitabha Palmer
doaj   +1 more source

DECORIN, a triceps‐derived myokine, protects sorted β‐cells and human islets against chronic inflammation associated with type 2 diabetes

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract Aim Pancreatic β‐cells are susceptible to inflammation, leading to decreased insulin production/secretion and cell death. Previously, we have identified a novel triceps‐derived myokine, DECORIN, which plays a pivotal role in skeletal muscle‐to‐pancreas interorgan communication.
Allan Langlois, Julien Cherfan, Emmanuelle Meugnier, Ahmad Rida, Caroline Arous, Claude Peronet, Harzo Hamdard, Bader Zarrouki, Bernhard Wehrle‐Haller, Michel Pinget, Siobhan M. Craige, Karim Bouzakri   +11 more
wiley   +1 more source

RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability

Life Science Alliance, 2022
Over the last decades, organoids have been established from most of the tissue-resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalised medicine. In recent years, several reports hinted at intraculture organoid variability, but a systematic analysis
Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz   +6 more
openaire   +3 more sources

Photoabbaubare Hydrogele auf Cumarin‐Basis ermöglichen die Zwei‐Photonen kontrollierte subtraktive Biofabrikation bei 300 mm s−1

Angewandte Chemie, Volume 136, Issue 45, November 4, 2024.
Cumarin‐basierte photodegradierbare Hydrogele ermöglichen schnelles, zweiphotonensubtraktives 3D‐Mikrodrucken und lasergesteuerte Zellwachstumsführung auf Abruf, wodurch neue Wege für bio‐medizinische Anwendungen, wie z. B. die raum‐zeitliche Gewebekonstruktion, eröffnet werden.
Wanwan Qiu, Christian Gehre, Jaime Pietrantuono Nepomuceno, Yinyin Bao, Zhiquan Li, Ralph Müller, Xiao‐Hua Qin   +6 more
wiley   +1 more source

Organoid Medicine in Hepatology [PDF]

Clinical Liver Disease, 2020
Answer questions and earn https://www.wileyhealthlearning.com/Activity/7025323/disclaimerspopup.aspx.
Kokoro Sakabe, Takanori Takebe, Akihiro Asai   +2 more
openaire   +2 more sources