Results 11 to 20 of about 479 (131)
Medicina, 2023 Há muitos anos a cultura celular bidimensional (2D) é utilizada como modelo de estudo de doenças, possuindo grande importância na medicina regenerativa, apesar de ainda conter limitações significativas.
Raysa Taynara Vasconcelos de Souza +6 more
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Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Review on the Vascularization of Organoids and Organoids-on-a-Chip [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The use of human cells for the construction of 3D organ models in vitro based on cell self-assembly and engineering design has recently increased in popularity in the field of biological science. Although the organoids are able to simulate the structures and functions of organs in vitro, the 3D models have difficulty in forming a complex vascular ...
Xingli Zhao +10 more
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Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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Organoids and Colorectal Cancer [PDF]
Cancers, 2021 Organoids were first established as a three-dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC)
Antonio Barbáchano +6 more
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Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
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INRAE Productions Animales, 2023 L’intestin est un organe complexe aux fonctions multiples. En effet, il participe à la digestion et l'absorption des nutriments et protège l’individu des agressions par des agents pathogènes intestinaux en assurant un rôle de barrière.
Agnès WIEDEMANN +1 more
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Die Linienmuster der Haut und ihre Dermatosen
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 4, Page 341-365, April 2020., 2020 Zusammenfassung Die Kenntnis der Linienmuster der Haut stellt eine Schlüsselkompetenz für jeden Dermatologen dar. Vier Hauptgruppen von Linienmustern sind relevant: Langer‐Linien, Dermatome, Blaschko‐Linien und exogene Muster. Die Langer‐Linien markieren die Richtung der geringsten Spannung der Haut und sind diagnostisch wichtig für einige ...
Sonja Senner +3 more
wiley +1 more source
Organoids are not organs: Sources of variation and misinformation in organoid biology
Stem Cell Reports, 2023 In the past decade, the term organoid has moved from obscurity to common use to describe a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of the in vivo organ it models. The term organoid is now applied to structures formed as a result of two distinct processes: the capacity for adult epithelial stem cells ...
Kim Bak Jensen, Melissa Helen Little
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Organoides: posibles aplicaciones en la Química Medicinal [PDF]
, 2022 Los avances en la biología de células madre y en el desarrollo de cultivos en tres dimensiones han permitido la generación de nuevos modelos celulares denominados organoides. Los organoides son estructuras multicelulares y autoorganizadas que recapitulan
Pagotto, Romina
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