Results 11 to 20 of about 1,209 (126)
Organoides: fundamentos, presente y futuro [PDF]
Revista Peruana de Medicina Experimental y Salud Pública, 2022 Los organoides son estructuras miniaturizadas, generadas principalmente a partir de células madre pluripotentes inducidas, que se cultivan en el laboratorio conservando sus características innatas o adquiridas.
José Amiel-Pérez +2 more
doaj +6 more sources
Organoides de cérebro como modelos de doenças de Alzheimer e Parkinson: uma revisão narrativa sobre as perspectivas para medicina regenerativa e personalizada [PDF]
Medicina, 2023 Há muitos anos a cultura celular bidimensional (2D) é utilizada como modelo de estudo de doenças, possuindo grande importância na medicina regenerativa, apesar de ainda conter limitações significativas.
Raysa Taynara Vasconcelos de Souza +6 more
doaj +5 more sources
Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy. [PDF]
Br J Surg, 2019 Organoid technology was used to create a preclinical model for evaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases from colorectal cancer. Current HIPEC regimens were tested and a novel rational treatment combination of mitomycin C with inhibitors of ATR was investigated.
Ubink I +13 more
europepmc +2 more sources
Lippia origanoides and Thymus vulgaris Essential Oils Synergize with Ampicillin against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli [PDF]
Microorganisms(1) Background: Could compounds such as monoterpenes and sesquiterpenes present in essential plant oils inhibit bacterial growth as an alternative to help mitigate bacterial resistance?
Levi Jafet Bastida-Ramírez +7 more
doaj +2 more sources
Afrontar los desafíos éticos del consentimiento informado para la donación de tejido cerebral [PDF]
Medicina y ÉticaLa enorme promesa médica de los organoides humanos ha llevado a grandes instituciones de investigación y organismos nacionales a crear bancos de tejido cerebral.
Amitabha Palmer
doaj +3 more sources
Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
+9 more sources
Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
openaire +2 more sources
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj +7 more sources
ARS Medica, 2023 Introducción: La pandemia causada por SARS-CoV-2 ha impactado al mundo gravemente en diversos ámbitos y con ello ha surgido la necesidad de contar con herramientas con mayor relevancia fisiológica para investigar patologías complejas como el COVID-19 ...
Caroline Weinstein +4 more
doaj +1 more source
Avant-propos du dossier « Cellules souches et Organoïdes : réalités et perspectives »
INRAE Productions Animales, 2023 Cellules souches et organoïdes, versions simplifiées d’organes, sont des outils biologiques qui permettent des avancées majeures en biologie et en médecine et qui suscitent de nombreux espoirs tout en réduisant les expériences sur les animaux.
Françoise MÉDALE +4 more
doaj +1 more source