Results 171 to 180 of about 82,310 (303)

STAR Protocols question-and-answer series: Organoids. [PDF]

STAR Protoc
Bhanot H.
europepmc   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Bioreactors for cardiac organoids

reservedI bioreattori comprendono molte delle strumentazioni necessarie per creare un ambiente favorevole alla crescita cellulare. Una delle loro applicazioni è la coltura di organoidi, strutture tridimensionali che replicano organi o tessuti nativi. Si
LIGUORO, MARIA FRANCESCA
core  

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Standard: human breast cancer organoids derived from diverse clinical sample sources. [PDF]

Cell Regen
Chen Z, Xu N, Chen M, Hu J, Yu Z, Zhu S, Zhang Y, Zhang R, Wang K, Wang S, Gao D, Ma F, Zhang J, Wu J, Xu B, Song E, Huang J.   +16 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Maternal-fetal interface organoids: a new era in pregnancy research. [PDF]

Front Bioeng Biotechnol
Gao J, Sun H, Yang S, Yao X.
europepmc   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

An AI-integrated organoid platform enables high-throughput functional evaluation of bioactive metal ions. [PDF]

Bioact Mater
Shao Y, Wang Y, Wang Y, Xu J, Li P, Zhao J, Du X, Liu X, Xu S, Wang L, Fan Z, Yang Y, Guo Y, Chen K, Wang C, Zhang Y, Xue F, Ge J, Chu C, Chen Z, Gu Z, Bai J.   +21 more
europepmc   +1 more source

Vascularizing the brain organoids

Journal of Molecular Cell Biology, 2022
Xin-Yao Sun, Zhen-Ge Luo
openaire   +2 more sources