Results 201 to 210 of about 94,019 (259)

Morphogen-Directed, High-Throughput Development of hiPSC-Derived Telencephalic Organoids for Comparative In Vitro Phenotyping. [PDF]

Curr Protoc
Whye D, Norabuena EM, Afshar-Saber W, Lewis B, Polanco TJ, Wood D, Sahin M, Buttermore ED.   +7 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Human Gallbladder Cancer Organoids. [PDF]

Cell Prolif
Xiang D, Gong T, Zhu Y, Jia B, Zhang C, Tang N, Wang W, Wang Y, Zhong L, Zou Y, Zhang J, Zhou Z, Xing L, Zhou C, Zhu D, Liu Z, Chen G, Wang X, Wang Z, He A, Wang Y, Liu Z, Wang J, Xu F, Gao G, Kang X, Gong S, Kong X, Dong C, Ma A, Niu G, Wei G, Zhao H, Lu X, Cao J, Zhao T, Zhang Z, Liu Y.   +37 more
europepmc   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Human brain organoids record the passage of time over multiple years. [PDF]

Nature
Faravelli I, Antón-Bolaños N, Wei A, Faits T, Kumar AS, Andreadis S, Kastli R, Crespo MM, Steiger M, Leible D, Zhang E, An B, Meirovitch Y, Silwal S, Yang SM, Kovacsovics A, Adiconis X, Kretzmer H, Levin JZ, Boyden ES, Lichtman J, Regev A, Meissner A, Arlotta P.   +23 more
europepmc   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Establishment of a Porcine Small Intestinal Organoid Model for Porcine Rotavirus Infection. [PDF]

Animals (Basel)
Wei H, Wu W, Liu M, Li M, Zhang J, Deng S.   +5 more
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine. [PDF]

Cell Prolif
Wang T, Qu X, Si J, Meng J, Zhang T, Niu S.   +5 more
europepmc   +1 more source