Results 231 to 240 of about 112,967 (355)

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

iPSC-based hepatic organoids reveal a heterozygous MYO5B variant as driver of intrahepatic cholestasis. [PDF]

Hepatol Commun
Sgodda M, Gebel E, Dignas L, Alfken S, Eggenschwiler R, Stalke A, Dröge C, Pfister ED, Baumann U, Luedde T, Esposito I, Keitel V, Cantz T.   +12 more
europepmc   +1 more source

A novel intestinal organoid-based in vitro co-culture system to dissect out the initial host defense system [PDF]

, 2016
Atsushi Mizoguchi
openalex   +1 more source

A Compartmentalized Joint‐on‐chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma, Shima Salehi, Michela Anna Polidoro, Matteo Moretti, Marco Rasponi, Silvia Lopa, Paola Occhetta   +6 more
wiley   +1 more source

Deciphering brain organoid heterogeneity by identifying key quality determinants. [PDF]

Commun Biol
Boerstler T, Kachkin D, Gerasimova E, Zagha N, Furlanetto F, Nayebzade N, Zappia L, Boisvert M, Farrell M, Ploetz S, Prots I, Regensburger M, Günther C, Winkler J, Gupta P, Theis F, Karow M, Falk S, Winner B, Krach F.   +19 more
europepmc   +1 more source

Establishment of mouse intestinal crypt stem cell-containing, self-sustaining organoids.

, 2014
Ning Wang, Hongyu Zhang, Bingqiang Zhang, Wei Liu, Zhonglin Zhang, Min Qiao, Hongmei Zhang, Deng Fang, WU Ning-ning, Xian Chen, Wen Sheng, Junhui Zhang, Liao Zhan, Qian Zhang, Yan Zhengjian, Liangjun Yin, Ye Jixing, Youlin Deng, H. Luu Hue, C. Haydon Rex, Houjie Liang, He Tong-Chuan   +21 more
openalex   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Protocol for purifying primitive neural progenitors by fractional passaging to generate astroglia-enriched cerebral organoid. [PDF]

STAR Protoc
Aluru K, Dang R, Jin M, Jiang P.
europepmc   +1 more source

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids [PDF]

, 2016
Thierry Jardé, Bethan Lloyd‐Lewis, Mairian Thomas, Howard Kendrick, Lorenzo Melchor, Lauriane Bougaret, Peter Watson, Kenneth Ewan, Matthew J. Smalley, Trevor Dale   +9 more
openalex   +1 more source

TBC1D22B Regulates ER‐to‐Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer

Advanced Science, EarlyView.
TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Flavia Martino, Mariadomenica Lupi, Alessandra Murabito, Fabio Bedin, Giulia Villari, Linda Andreoli, Stefano Freddi, Bronislava Matoskova, Rosa Pennisi, Stella Fontana, Amir Fardin, Gaelle Boncompain, Franck Perez, Federico Bussolino, Alessandro Cuomo, Sara Sigismund, Letizia Lanzetti   +16 more
wiley   +1 more source