Results 241 to 250 of about 106,655 (301)

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

Protocol for characterization of spatiotemporal network dynamics in cortical and hippocampal assembloids. [PDF]

STAR Protoc
Guzman AR, McCrimmon CM, Toker D, Novitch BG, Watanabe M, Samarasinghe RA.   +5 more
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Ginsenoside Rg3 promotes chemosensitivity in lung adenocarcinoma organoids via apoptotic pathways. [PDF]

Front Pharmacol
Liu M, Li Y, Han B, Zeng N, Wei X, Xing X, Jiang Z, Liu X, Zhang C.   +8 more
europepmc   +1 more source

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

Engineering immune-competent niches: strategies, applications, and translational hurdles in ovarian cancer organoid models. [PDF]

Front Immunol
Chen Y, Xu N, Dong M, Liu W, Liu Z, Sun G, Jia Y.   +6 more
europepmc   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Nondestructive In-Situ Measurement of Alkaline Phosphatase Activity of Human Intestinal Organoids in Hydrogel Domes Using Scanning Electrochemical Microscopy. [PDF]

Anal Chem
Utagawa Y, Ogihara A, Shinoda Y, Li F, Abe H, Shiku H, Ino K.   +6 more
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Long-term culture of patient-derived pheochromocytoma organoids. [PDF]

Front Endocrinol (Lausanne)
van den Berg MF, Timmermans-Sprang EPM, Zethof J, Kusters B, Olthaar A, van Herwaarden AE, van Wolferen ME, Timmers HJLM, Kooistra HS, Dona M, Galac S.   +10 more
europepmc   +1 more source