Results 271 to 280 of about 112,967 (355)

Development of a 3D Human Colon Model Along with Bioelectronics for the Induction and Monitoring of Diseases

Advanced Science, EarlyView.
We present a functional three‐dimensional in‐vivo‐mimicking human colon (3D‐IVM‐HC) model engineered via Freeform Reversible Embedding of Suspended Hydrogels bioprinting with gelatin methacrylate (GelMA)/alginate hydrogels. This 3D non‐animal model replicates crypt‐like architectures, epithelial polarization, and stromal–tumor interactions, showing ...
Jorge Alfonso Tavares‐Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour   +7 more
wiley   +1 more source

The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration. [PDF]

Nat Commun
Göttert S, Thiele Orberg E, Fan K, Heinrich P, Matthe DM, Khalid O, Klostermeier L, Suriano C, Strieder N, Gebhard C, Vonbrunn E, Mamilos A, Hirsch D, Meedt E, Kleigrewe K, Hiergeist A, Schwarz A, Gläsner J, Ghimire S, Joachim L, Voll F, Neuhaus K, Janssen KP, Perl M, Pielmeier F, Ruland J, Kreutz M, Weber D, Schmidl C, Köhler N, Tschurtschenthaler M, Hoffmann P, Edinger M, Wolff D, Bassermann F, Rehli M, Haller D, Evert M, Hildner K, Büttner-Herold M, Herr W, Gessner A, Heidegger S, Holler E, Poeck H.   +44 more
europepmc   +1 more source

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

, 2016
Jason Dang, Shashi Kant Tiwari, Gianluigi Lichinchi, Yue Qin, Veena S. Patil, Alexey M. Eroshkin, Tariq M. Rana   +6 more
openalex   +1 more source

Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities

Advanced Science, EarlyView.
The tongue's anterior epithelium is maintained by region‐specific stem/progenitor cells, yet in vitro models are limited. Long‐term expanding organoids are developed from adult mouse anterior tongue that retain region‐specific identity, cellular diversity, and gene regulatory features. These organoids differentiate into keratinocytes, Merkel‐like cells,
Seok‐Young Kim, Laurens H. G. Verweij, Lin Lin, Johan H. van Es, Jay Slack, Chris Winkel, Tito Candelli, Philip Lijnzaad, Thanasis Margaritis, Gerben E. Breimer, Karin Sanders, Marc van de Wetering, Hans Clevers   +12 more
wiley   +1 more source

Standards for Organoids

International Journal of Stem Cells
openaire   +2 more sources

Charting bioethical frontiers: China's human organoid guidelines in a global context. [PDF]

Mil Med Res
Zhou LB, Lei YT, Han XX.
europepmc   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

hPSC-derived lung and intestinal organoids as models of human fetal tissue

, 2016
Megan Aurora, Jason R. Spence
openalex   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment. [PDF]

Cell Commun Signal
Carmi I, Orosz A, Hajdó S, Zeöld A, Hegedűs T, Kelemen-Győri D, Pozsár J, Tölgyes T, Wiener Z.   +8 more
europepmc   +1 more source