Results 271 to 280 of about 120,310 (351)

Cartilage organoids: an emerging platform for novel osteoarthritis therapies. [PDF]

Front Cell Dev Biol
Gao B, Chen Z, Long Y, He F, Gan D, Yi W, Xiao G, Ren J, Qin L.   +8 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Synergism between Distribution, Mechanistic and Omics Analyses in Studies on Assessing Environmental Exposure and Human Health Impact. [PDF]

Environ Health (Wash)
Siu KWM.
europepmc   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Lessons on multicellular two- (2D) and three-dimensional (3D) culture in parasitology: Insights, challenges and future directions. [PDF]

Int J Parasitol
Smith D, Perez MG, Garner ME, Anderson WM, Britton C, Duque-Correa MA, Calvani NED.   +6 more
europepmc   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, EarlyView.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

Cartilage organoids bridging bench to bedside: A steroid-free strategy for early osteoarthritis repair. [PDF]

Mater Today Bio
Zhang X, Lin Z, Lv M, Lu C, Hu B, Yu W, Wang Z, Liu X, Zhang C, Wu D, He Y.   +10 more
europepmc   +1 more source

Alveolar Organoids in Lung Disease Modeling [PDF]

Enkhee Purev, Karim Bahmed, Beata Kośmider   +2 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Development of synovial sarcoma organoids exhibiting ferroptosis resistance despite low malic enzyme 1 expression. [PDF]

Sci Rep
Wakamatsu T, Yamada Y, Yoshida K, Matsuoka Y, Sasagawa S, Nagamine N, Shizuma K, Suzuki R, Tamiya H, Imura Y, Nakai S, Okada S, Yagi T, Yoshida KI, Kakunaga S, Yui Y, Takenaka S.   +16 more
europepmc   +1 more source