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Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P Lutolf
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Cryoletters, 2023
Organoids represent indispensable opportunities for biomedicine, including drug discovery, cancer biology, regenerative and personalised medicine or tissue and organ transplantation. However, the lack of optimised preservation strategies limits the wide use of organoids in research or clinical fields.
O, Rogulska, J, Havelkova, Y, Petrenko
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Organoids represent indispensable opportunities for biomedicine, including drug discovery, cancer biology, regenerative and personalised medicine or tissue and organ transplantation. However, the lack of optimised preservation strategies limits the wide use of organoids in research or clinical fields.
O, Rogulska, J, Havelkova, Y, Petrenko
openaire +2 more sources
Nature Reviews Cancer, 2019
Neal et al. have successfully established patient-derived organoids of tumour epithelia retaining native immune cells, thereby recapitulating tumour microenvironment diversity and enabling immuno-oncology studies.
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Neal et al. have successfully established patient-derived organoids of tumour epithelia retaining native immune cells, thereby recapitulating tumour microenvironment diversity and enabling immuno-oncology studies.
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Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M Wells
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Commercialization of Organoids
Trends in Molecular Medicine, 2020Organoids have been successfully exploited for drug screening, disease modeling, pathogenesis, and regenerative medicine. Herein, we discuss the progress achieved in the commercialization of organoids in the last few years. We further elaborate on the concept of organoid biobank and highlight ethical and regulatory issues surrounding organoid research ...
Deepak, Choudhury +2 more
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Nature Biotechnology, 2019
Human brain organoids are endowed with regional topography using engineered signaling centers.
Yuki Miura, Sergiu P. Pașca
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Human brain organoids are endowed with regional topography using engineered signaling centers.
Yuki Miura, Sergiu P. Pașca
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