Results 281 to 290 of about 120,310 (351)

Reviewer #3 (Public Review): Single-cell RNA sequencing of iPSC-derived brain organoids reveals Treponema pallidum infection inhibiting neurodevelopment

Qiu‐Yan Xu, Yongjing Wang, Yun He, Xinqi Zheng, Man-Li Tong, Yu Lin, Tian‐Ci Yang   +6 more
openalex   +1 more source

Organoids of liver diseases: From bench to bedside

, 2019
Lijun Wu, Ziyan Chen, Yi Wang, Jungang Zhao, Xiaozai Xie, Gang Chen   +5 more
openalex   +2 more sources

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Optimized patient-derived lung cancer organoids recapitulating the immune landscape for precision therapy evaluation. [PDF]

Cell Oncol (Dordr)
Xing H, Liu R, Chen Y, Chen X, Gao X, Shen C, Zhang S, Tang Y, Wu L, You M, Xu P, Xia B.   +11 more
europepmc   +1 more source

ImageJ macros for quantitative analysis of cell death in human intestinal organoids

Pang, Jiyi, Whitehead, Lachlan
openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids. [PDF]

Sci Rep
Klockner I, Yeturi M, Rust TE, Stein JL, Zylka MJ.   +4 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

From Cells to Organoids: Approaches, Regulatory Mechanisms, Applications, and Challenges of Organoids. [PDF]

Cells
Wang L, Chen A, Zhang D, He Z.
europepmc   +1 more source