Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease. [PDF]
PLoS PathogOrientia tsutsugamushi is an obligate intracellular bacterium found in Leptotrombidium mites that causes the human disease scrub typhus. A distinguishing feature of O.
Chaichana P +9 more
europepmc +6 more sources
Molecular diagnosis and genotyping of Orientia tsutsugamushi in Maesot and Chiangrai, Thailand. [PDF]
Front Trop Dis, 2023 Introduction: Scrub typhus is a neglected tropical disease with an estimated 1 million cases annually. The Asia-Pacific region is an endemic area for scrub typhus, especially in Thailand.
Rungrojn A +8 more
europepmc +3 more sources
Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression [PDF]
Nature CommunicationsHow intracellular bacteria subvert the major histocompatibility complex (MHC) class I pathway is poorly understood. Here, we show that the obligate intracellular bacterium Orientia tsutsugamushi uses its effector protein, Ank5, to inhibit nuclear ...
Haley E. Adcox +6 more
doaj +2 more sources
Case Report: Encephalitis with Initial Manifestation of Orientia Tsutsugamushi Infection Detected by Metagenomic Next-Generation Sequencing [PDF]
Infection and Drug ResistanceSong Han,1,* Suge Yang,1,* Yun Wang,2 Yingying Xu2 1The Second Hospital of Shandong University, Cheeloo College of Medicine of Shandong University, Shandong University, Jinan, 250033, People’s Republic of China; 2Department of Neurology Medicine,
Han S, Yang S, Wang Y, Xu Y
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Orientia tsutsugamushi, the agent of scrub typhus
WikiJournal of Medicine, 2019 Orientia tsutsugamushi is a mite-borne bacterium belonging to the family Rickettsiaceae and is responsible for the disease scrub typhus in humans. It is an obligate intracellular parasite of trombiculid mites, in which natural transmission is maintained ...
Kholhring Lalchhandama
doaj +2 more sources
Genetic Characterization of Orientia tsutsugamushi, Bhutan, 2015. [PDF]
Emerg Infect DisTshokey T +4 more
europepmc +3 more sources
Frontiers in Medicine, 2022 Scrub typhus is a potentially severe rickettsiosis, caused by Orientia tsutsugamushi in the Asia-Pacific region. Recently, however, two distinct pathogens, “Candidatus Orientia chuto” and “Candidatus Orientia chiloensis”, have been discovered in the ...
Ju Jiang +10 more
doaj +1 more source
Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China. [PDF]
Vet Med SciScrub typhus is caused by Orientia tsutsugamushi (OT). In this study, the detection rates of OT in patients and small mammals were 28.13% (18/64) and 13.98% (13/93), respectively. Nine full‐length 56‐kDa TSA genes were identified, comprising four distinct genotypes: Karp‐like (n = 3), Kato‐like (n = 3), Gilliam (n = 2), and TA763 (n = 1). Recombination
Chen L +9 more
europepmc +2 more sources
Analysis of Orientia tsutsugamushi promoter activity [PDF]
Pathogens and Disease, 2021 ABSTRACT Orientia tsutsugamushi is an obligate intracellular bacterium that causes scrub typhus, a potentially fatal rickettsiosis, and for which no genetic tools exist. Critical to addressing this technical gap is to identify promoters for driving expression of antibiotic resistance and fluorescence reporter genes in O.
Jason R Hunt, Jason A Carlyon
openaire +2 more sources