Results 61 to 70 of about 5,617 (192)

Active Escape of Orientia tsutsugamushi from Cellular Autophagy [PDF]

Infection and Immunity, 2013
ABSTRACT Orientia tsutsugamushi , the causative agent of scrub typhus, is an obligate intracellular pathogen. After entry into host cells, the bacterium rapidly escapes from the endosomal pathway and replicates in the cytosol of eukaryotic host cells. Here we show that O.
Youngho, Ko, Ji-Hye, Choi, Na-Young, Ha, Ik-Sang, Kim, Nam-Hyuk, Cho, Myung-Sik, Choi   +5 more
openaire   +2 more sources

Diagnosis of Rickettsial infection by Multiplex Real-time PCR in Febrile Pediatric Patients Admitted in a Tertiary Care Hospital at Chennai, South India

Journal of Pure and Applied Microbiology
Rickettsioses caused by Rickettsia and Orientia spp. are the re-emerging diseases in India, which are grossly underdiagnosed, particularly among children.
Rajagopal Murali, Sivasambo Kalpana, Karthick Shanmugam, Prabu Dhandapani   +3 more
doaj   +1 more source

Scrub Typhus Outbreak in Chonburi Province, Central Thailand, 2013

Emerging Infectious Diseases, 2018
Investigation of a scrub typhus outbreak in Thailand during September 2013 found that 9.1% of Thai soldiers and 11.1% of residents living in areas surrounding training sites had antibodies against the causative agent, Orientia tsutsugamushi.
Wuttikon Rodkvamtook, Narupon Kuttasingkee, Piyada Linsuwanon, Yutthapong Sudsawat, Allen L. Richards, Maneerat Somsri, Noppadon Sangjun, Chien-Chung Chao, Silas Davidson, Elizabeth Wanja, Jariyanart Gaywee   +10 more
doaj   +1 more source

Seroprevalence and Genotypic Characterization of Orientia tsutsugamushi in Febrile Pediatric Patients Admitted in Tertiary Care Hospital of Chennai, South India

Journal of Pure and Applied Microbiology, 2023
Scrub typhus is one of the important vector borne illness which is largely underdiagnosed, particularly in children. It causes mild febrile illness to severe complications.
Rajagopal Murali, Sivasambo Kalpana, Panneerselvam Satheeshkumar, Prabu Dhandapani   +3 more
doaj   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

435. Serological Cross-Reactivity Between Rickettsia japonica and Orientia tsutsugamushi, and Among Orientia tsutsugamushi Serotypes [PDF]

Open Forum Infectious Diseases, 2018
BACKGROUND: The rickettsial diseases Japanese spotted fever (JSF) and scrub typhus (ST) are caused by Rickettsia japonica and Orientia tsutsugamushi, respectively. The diseases share clinical symptoms, such as fever, rash, and eschar. However, there are no systematical investigations of the serological cross-reactivity between R.
Sando, Eiichiro, Ariyoshi, Koya, Fujita, Hiromi   +2 more
openaire   +1 more source

Metabolic responses to Orientia tsutsugamushi infection in a mouse model. [PDF]

PLoS Neglected Tropical Diseases, 2015
Tsutsugamushi disease is an infectious disease transmitted to humans through the bite of the Orientia tsutsugamushi-infected chigger mite; however, host-pathogen interactions and the precise mechanisms of damage in O.
Jeeyoun Jung, Youngae Jung, Byoungchul Gill, Changhun Kim, Kyu-Jam Hwang, Young-Ran Ju, Hye-Ja Lee, Hyuk Chu, Geum-Sook Hwang   +8 more
doaj   +1 more source

A Multiplex PCR assay for a differential diagnostic of rickettsiosis, Lyme disease and scrub typhus

Journal of Vector Borne Diseases, 2022
Background & objectives: Coexistence of tick-borne diseases in some regions in Latin America makes the diagnosis difficult due to shared initial signs and symptoms. Rickettsiosis, Lyme disease and recently, scrub typhus are gaining more importance.
Gaspar Peniche-Lara, Isamara Moo-Salazar, Karla Dzul-Rosado   +2 more
doaj   +1 more source

Silent Threat: Multi‐Organ Failure in Neonatal Scrub Typhus Without Traditional Markers

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Scrub typhus, an acute zoonotic disease from Orientia tsutsugamushi, is uncommon in newborns and presents atypical symptoms. Untimely diagnosis and treatment can lead to a prolonged and potentially fatal course. Early diagnosis and treatment are essential for better patient outcomes.
Li Hu, Shuyan Li, Fangjian Gao, Shiguang Diao, Xiaoyan Liu, Jianwu Qiu   +5 more
wiley   +1 more source

New Orientia tsutsugamushi Strain from Scrub Typhus in Australia

Emerging Infectious Diseases, 1998
In a recent case of scrub typhus in Australia, Orientia tsutsugamushi isolated from the patient's blood was tested by sequence analysis of the 16S rDNA gene. The sequence showed a strain of O. tsutsugamushi that was quite different from the classic Karp,
Dimitri M. Odorico, Stephen R. Graves, Bart J. Currie, Julian Catmull, Zoltan Nack, Sharon Ellis, Ling Wang, David J. Miller   +7 more
doaj   +1 more source