Results 161 to 170 of about 838,055 (333)

The origin of species by means of natural selection; or, the preservation of favored races in the struggle for life, by Charles Darwin ... with additions and corrections from 6th and last English ed ...

, 1915
Charles Darwin
openalex   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes. [PDF]

Proc Natl Acad Sci U S A, 2023
Babajanyan SG, Wolf YI, Khachatryan A, Allahverdyan A, Lopez-Garcia P, Koonin EV.   +5 more
europepmc   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

An interdisciplinary effort to understand chemical organizations at the origin of life. [PDF]

iScience, 2023
Jeancolas C, Singh AY, Jain S, Krishna S, Nghe P.   +4 more
europepmc   +1 more source

The origin of species : by means of natural selection, or, The preservation of favoured races in the struggle for life / by Charles Darwin.

, 1889
Charles Darwin
openalex   +2 more sources

At the origin of life

, 2015
There are close interactions between the Earth's climate and life, and this has been the case since the beginning. By studying the history of life on Earth, we understand that the atmosphere probably created it and that life has not stopped modifying this atmosphere in response to the selection pressures resulting from the major transitions that the ...
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Volcanic Island lightning prebiotic chemistry and the origin of life in the early Hadean eon. [PDF]

Nat Commun, 2023
Bada JL.
europepmc   +1 more source

The origin of species by means of natural selection; or, The preservation of favored races in the struggle for life,

, 1889
Charles Darwin
openalex   +2 more sources