Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Golden Horde Cities Of The North Caucasus: Origin, Population, Everyday Life
, 2019 Khadzhi-Murat Sabanchiev +4 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Methane formation driven by light and heat prior to the origin of life and beyond. [PDF]
Nat Commun, 2023 Ernst L +6 more
europepmc +1 more source
Fourth Symposium on Chemical Evolution and the Origin and Evolution of Life [PDF]
This symposium was held at the NASA Ames Research Center, Moffett Field, California, July 24-27, 1990. The NASA exobiology investigators reported their recent research findings. Scientific papers were presented in the following areas: cosmic evolution of
Andersen, Dale T. +3 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes. [PDF]
Proc Natl Acad Sci U S A, 2023 Babajanyan SG +5 more
europepmc +1 more source
Promotion of protocell self-assembly from mixed amphiphiles at the origin of life
Nature Ecology & Evolution, 2019 S. Jordan +5 more
semanticscholar +1 more source
Materials of the Third Conference of Young Scientists, dedicated to Charles Darwin's 200th Birthday and the 150th Anniversary of the publication of his main book «On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life» (9-10 June 2009) [PDF]
, 2009 Olena V. Balynska +16 more
openalex +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source